Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance

Not Applicable

Completed

• Conditions: Obesity; Diabetes; Insulin Resistance; Fatty Liver
• Interventions: Other: SFA diet; Other: PUFA Diet

• Registration Number: NCT01038102
• Lead Sponsor: Uppsala University

Brief Summary

The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects

Detailed Description

Specific goals:

1. Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes

2. Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content

3. Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity

Study Timeline

• Study Start: 2009-02
• Status Verified: 2009-12
• Study First Submitted: 2009-12-21
• Study First Submitted QC: 2009-12-21
• Study First Posted: 2009-12-23
• Primary Completion: 2010-04
• Study Completion: 2010-04
• Last Update Submitted: 2010-07-12
• Last Update Posted: 2010-07-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• abdominal obese subjects with or without type 2 diabetes
• sagittal abdominal diameter >25cm

Exclusion Criteria

• insulin treatment
• history of serious cardiovascular events
• morbid obesity
• claustrophobia (relative criterion)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
SFA diet	SFA diet	Diet high in saturated fat (15 E%)
PUFA diet	PUFA Diet	Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%)

Primary Outcome Measures

Name	Time	Method
Hepatic steatosis by MRT	10 weeks

Secondary Outcome Measures

Name	Time	Method
Changes in adipose tissue gene expression and lipogenic enzyme activity	10 weeks
Insulin resistance by oral glucose tolerance test	10 weeks

Trial Locations

Locations (1)

Uppsala University Hospital, Uppsala Science Park; 🇸🇪 Uppsala, Sweden