Polyunsaturated Fatty Acids Supplementation and Blood Metabolome

Not Applicable

• Conditions: Healthy
• Interventions: Other: The high PUFA diet group

• Registration Number: NCT03892486
• Lead Sponsor: Poznan University of Life Sciences

Brief Summary

Analysis of the effect of dietary intervention based on increased polyunsaturated fatty acid intake on health. Specifically changes in blood lipid profile, as well as proteomic and metabolomic profiles of healthy adults will be analyzed.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-01
• Study First Submitted: 2019-02-21
• Status Verified: 2019-03
• Study First Submitted QC: 2019-03-26
• Last Update Submitted: 2019-03-26
• Study First Posted: 2019-03-27
• Last Update Posted: 2019-03-27
• Primary Completion: 2019-04
• Study Completion: 2019-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• good health,
• proper body weight
• not meeting the needs for polyunsaturated fatty acids

Exclusion Criteria

• increased body weight,
• limited communication to an extent that makes it impossible to carry out a food interview,
• eating disorders (according to food history),
• metabolic diseases,
• pregnancy,
• lactation,
• taking drugs that influence the metabolism of lipids or carbohydrates

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
The high PUFA diet group	The high PUFA diet group	This will receive detailed nutritional recommendations and will consume at least 4 table spoons of olive oil or 30 grams of nuts daily for 12 weeks.

Primary Outcome Measures

Name	Time	Method
Metabolite concentrations in plasma	12 weeks	Metabolite concentrations in plasma samples are measured by high resolution mass spectrometry at baseline and after the intervention
Nutrient intake	12 weeks	Nutrient intake (3-day food records)
Proteomic analysis of plasma	12 weeks	The aim is to identify biomarkers in the blood and to determine the differences between people from the control and the intervention group
Concentrations of lipoproteins and glucose	12 weeks	Serum concentrations of lipoproteins and glucose at baseline and after the intervention \[mg/dl\]

Secondary Outcome Measures

Name	Time	Method
Waist circumference	12 weeks	waist circumference at baseline and after the intervention
Body mass	12 weeks	body mass at baseline and after the intervention
Percentage body fat	12 weeks	percentage body fat at baseline and after the intervention
hip circumference	12 weeks	hip circumference at baseline and after the intervention
Height	12 weeks	height

Trial Locations

Locations (1)

Poznan University of Life Sciences; 🇵🇱 Poznań, Poland