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临床试验/NCT05796817
NCT05796817已完成不适用

Reducing Oxygen Consumption in Critical Care (ROCC)

Royal Brompton & Harefield NHS Foundation Trust1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2023年5月25日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
12
试验地点
1
主要终点
Arterial blood gas analysis - baseline

研究概览

简要总结

In normal practice oxygen supply can be easily met with existing hospital infrastructure. COVID - 19 however results in lung damage which greatly increases the amount of oxygen patients require - as a consequence some hospitals in the UK and other countries had situations where there was not enough oxygen for their inpatients.

COVID - 19 has caused many more patients to requiring assistance with their breathing using a ventilator. Due to the limited supply of sophisticated ventilators that 're-use' oxygen patients breathe out, some hospitals have used ventilators normally used by patients at home (domiciliary ventilators). Whilst these are inexpensive and commonly available, any oxygen the patient breathes out is simply released into the atmosphere.

The address this problem, and in turn reduce the oxygen demand on hospital infrastructure the biomedical engineering team (BME) at the Royal Brompton Hospital, London devised a simple 3-D printed modification which captures and reuses oxygen on commonly used domiciliary ventilators. Laboratory testing found this modification can increase the oxygen given by the ventilator without increasing the oxygen consumption of the ventilator - effectively reducing oxygen demand on hospital infrastructure.

This study will evaluate this modification in patients admitted to intensive care requiring assistance with their breathing. This will involve measuring oxygen levels on domiciliary ventilators (Breas Nippy 4+, ResMed Lumis 150 or Vivo 1, 2 or 3) with and without the modification and with small increases in oxygen supplied to the patient for a total study period of 2 hours.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patient in critical care using a ResMed LumisTM 150, Breas® Nippy 4+ or Vivo 1, 2 or 3 ventilator or deemed safe by treating consultant safe to switch to one.
  • 28% or more of entrained oxygen (FiO2)
  • Judged to be safe to tolerate increased fraction of inspired oxygen for periods of 10 minutes
  • Arterial line insitu for clinical reasons

排除标准

  • Thought to be clinically unstable during study protocol (2 hours)

结局指标

主要结局

Arterial blood gas analysis - baseline

时间窗: After 10 minutes

PaO2 with and without modification fitted

次要结局

  • Arterial blood gas - CO2(After 10 minutes of each experimental condition)
  • Arterial blood gas - modification and oxygen change(After 10 minutes of each experimental condition)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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