Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Hvidovre University Hospital
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Time in SpO2 target
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96 %. We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval.
Detailed Description
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96 %. We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval. Patients were prospectively enrolled in an observational study on a medical ward dedicated to patients with COVID-19. Closed-loop controlled oxygen was delivered by O2matic® which can deliver 0-15 liters/min and adjusts flow every second based on 15 seconds averaging of SpO2 measured by pulse oximetry. Lung function parameters were measured at admission.
Investigators
Ejvind Frausing Hansen
Chief Physician
Hvidovre University Hospital
Eligibility Criteria
Inclusion Criteria
- •Older than 18 years
- •Positive COVID-19 PCR analysis in pharyngeal swab or in tracheal secretion
- •Need oxygen supply to maintain SpO2 ≥ 92 %
- •Able to comply with continuous measurement of SpO2 by pulse oximetry.
Exclusion Criteria
- •Need of oxygen supply \> 10 liters/min at admission
Outcomes
Primary Outcomes
Time in SpO2 target
Time Frame: 1 week
Time in SpO2 target of 92-96 %
Secondary Outcomes
- Time with SpO2 < 85 %(1 week)
- Time with SpO2 not more than 2 % outside target(1 week)
- Time with SpO2 more than 2 % outside target(1 week)