Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Time in SpO2 target
研究概览
简要总结
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96 %. We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval.
详细描述
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96 %. We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval.
Patients were prospectively enrolled in an observational study on a medical ward dedicated to patients with COVID-19. Closed-loop controlled oxygen was delivered by O2matic® which can deliver 0-15 liters/min and adjusts flow every second based on 15 seconds averaging of SpO2 measured by pulse oximetry. Lung function parameters were measured at admission.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 years
- •Positive COVID-19 PCR analysis in pharyngeal swab or in tracheal secretion
- •Need oxygen supply to maintain SpO2 ≥ 92 %
- •Able to comply with continuous measurement of SpO2 by pulse oximetry.
排除标准
- •Need of oxygen supply > 10 liters/min at admission
结局指标
主要结局
Time in SpO2 target
时间窗: 1 week
Time in SpO2 target of 92-96 %
次要结局
- Time with SpO2 < 85 %(1 week)
- Time with SpO2 not more than 2 % outside target(1 week)
- Time with SpO2 more than 2 % outside target(1 week)
研究者
Ejvind Frausing Hansen
Chief Physician
Hvidovre University Hospital