The Impact of Age on Adaptive Immunity in Adults Infected With Respiratory Syncytial Virus
Overview
- Phase
- Not Applicable
- Intervention
- RSV A Memphis 37
- Conditions
- RSV Infection
- Sponsor
- Imperial College London
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Number of Participants With Challenge-related Adverse Events
- Status
- Completed
- Last Updated
- 3 months ago
Overview
Brief Summary
This study will for the first time systematically investigate the immune responses in an elderly cohort challenged with a well-defined RSV inoculum. With a global aging population and continuing difficulties in generating vaccines that can reliably induce protective immunity in the elderly, these data will indicate the targets at which development of vaccines against RSV and other infections should be directed.
Detailed Description
Respiratory syncytial virus (RSV) is one of the most common causes of chest infection worldwide, with 64 million episodes and 160,000 deaths each year. Despite this, it remains an underappreciated health problem and there are currently no specific treatments or vaccines against it. Although RSV infection is most frequent in young children, the majority of deaths occur in older adults, particularly in those with underlying heart and lung disease. This is believed to be due in part to the ageing immune system's reduced ability to protect against infection and symptomatic disease. However, little is known about the way human immune responses to RSV infection in older individuals differ from those of younger people. Further understanding of the mechanisms underlying immunity and potential impairments in these higher-risk people are therefore necessary. This project aims to study the role of T cells (which destroy virus-infected cells and are likely to be essential for recovery from infection) in healthy older volunteers after they have been given an RSV-induced common cold. Samples will be taken from the blood and respiratory tract in order to identify the differences in T cell responses that occur in older adults compared with their younger counterparts. Participants will be carefully screened to ensure they do not have any underlying health problems that might make them more at risk of severe disease and will be monitored closely throughout the course of infection. The investigators anticipate that T cell function even in healthy older individuals will be impaired compared to young adults, thus contributing in those with additional health problems to more severe disease. By analysing the networks of genes that are switched on and off, the investigators aim to identify the particular defects underlying these functional defects in order to ultimately define targets for novel treatments and T cell-stimulating vaccines.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy persons aged 60 to 75 years, able to give informed consent
- •Non smokers or ex-smokers with smokers with less than or equal to 5 pack years smoking history.
- •Spirometry within the normal range for age and height (+/- 15%)
- •FEV1/FVC \>70% pre-bronchodilator
Exclusion Criteria
- •Chronic respiratory disease (asthma, COPD, rhinitis, sinusitis) in adulthood
- •Inhaled bronchodilator or steroid use within the last 12 months
- •Habitual use of any medication or other product (prescription or over-the-counter) for symptoms of rhinitis or nasal congestion within the last 3 months
- •Acute upper respiratory infection (URI or sinusitis) in the past 6 weeks
- •Subjects with allergic symptoms present at baseline
- •Clinically relevant abnormality on chest X-ray
- •Those in close domestic contact (i.e. sharing a household with, caring for, or daily face to face contact) with children under 3 years, other elderly adults (\>65 years), immunosuppressed persons, or those with chronic respiratory disease
- •Subjects with known or suspected immune deficiency
- •Receipt of systemic glucocorticoids (in a dose ≥ 5 mg prednisone daily or equivalent) within one month, or any other cytotoxic or immunosuppressive drug within 6 months prior to challenge
- •Known IgA deficiency, immotile cilia syndrome, or Kartagener's syndrome
Arms & Interventions
Healthy, non-smoking or ex-smoking persons aged 60 to 75 years
RSV A Memphis 37 will be given as intra-nasal drops.
Intervention: RSV A Memphis 37
Outcomes
Primary Outcomes
Number of Participants With Challenge-related Adverse Events
Time Frame: 180 days
To determine the safety and tolerability of experimental challenge with RSV Memphis 37, assessed by the number of participants with challenge-related adverse events. This includes any AEs deemed at least possibly related to the study challenge intervention (RSV Memphis 37). Assessed from the time of inoculation to study completion (Day 180).
Secondary Outcomes
- Symptom Severity in RSV Infection(Day 0 to Day 14 (14 days))
- Nasal Viral Load Measurement in RSV Infection(Day 0 to Day 28 (28 days))