A Randomised Double-Blind Trial of Medical Treatment In Marfan Syndrome.
- Conditions
- Marfan Syndrome
- Registration Number
- EUCTR2005-000749-13-GB
- Lead Sponsor
- Cardiff University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Entry criteria:
? Clinical diagnosis of Marfan syndrome (Ghent criteria)
? Aged 16-50 years; either gender
On no treatment for Marfan syndrome, or on beta-blocker or other
monotherapy only
Are the trial subjects under 18? yes
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
? Previous aortic dissection or aortic surgery
? Severe aortic or mitral regurgitation; or cardiac disease unrelated
to Marfan Syndrome
? Pregnancy, or of child-bearing age if at risk of pregnancy
? Aortic diameter at sinotubular junction = 5.0 cm
? Contraindications to specific drug treatment: e.g. asthma
(?-blockers), or renal dysfunction defined as serum creatinine >150 µmol/l
(ACE inhibitor)
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method