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Safety and Effectiveness of Lamivudine When Given Once a Day Versus Twice a Day in Combination With Other Anti-HIV Drugs in HIV-Infected Adults Who Have Never Received Anti-HIV Drugs

Phase 2
Completed
Conditions
HIV Infections
Registration Number
NCT00004852
Lead Sponsor
Glaxo Wellcome
Brief Summary

The purpose of this study is to look at the safety and effectiveness of receiving lamivudine (3TC) once a day versus twice a day as part of an anti-HIV drug combination.

Detailed Description

Patients are randomized to receive the same total dosage of 3TC either twice a day (Group 1) or once a day (Group 2) in combination with ZDV and EFV over 48 weeks. Viral load measurements will be performed at Weeks 4, 8, 12, 16, 20, 24, and every 8 weeks thereafter.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
Not specified
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (62)

Phoenix Body Positive

🇺🇸

Phoenix, Arizona, United States

Pacific Oaks Research

🇺🇸

Beverly Hills, California, United States

AIDS Healthcare Foundation

🇺🇸

Los Angeles, California, United States

Tower ID Med Associates

🇺🇸

Los Angeles, California, United States

Davies Med Ctr / c/o HIV Institute

🇺🇸

San Francisco, California, United States

Kaiser Foundation Hospital

🇺🇸

San Francisco, California, United States

Harbor - UCLA Med Ctr

🇺🇸

Torrance, California, United States

Georgetown Univ Med Ctr

🇺🇸

Washington, District of Columbia, United States

George Washington Univ Med Ctr

🇺🇸

Washington, District of Columbia, United States

IDC Research Initiative

🇺🇸

Altamonte Springs, Florida, United States

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Phoenix Body Positive
🇺🇸Phoenix, Arizona, United States

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