The extent and time-frame of endogenous inhibitory effects after a cold pressor test using a conditioned pain modulation paradigm (ICE study)

Completed

Conditions: pijn systeem, onder andere tijdens slaapdeprivatie
pain thresholds before and after a cold pressor test

Registration Number: NL-OMON44617

Lead Sponsor: Sint Antonius Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

• Healthy male subjects
• Age 25-35 years
• Resident in Anesthesiology, Cardiology, Surgery, Internal Medicine, Orthopedics, Urology, Emergency Medicine.
• Ability to obtain informed consent
• Subject speaks Dutch
• Willingness to comply with study protocol

Exclusion Criteria

• Use of analgetics
• History of psychiatric or neurological disease
• Chronic pain disorders
• Diabetes Mellitus
• Systemic illness
• (History of) substance abuse (drugs, alcohol)
• Kidney disease
• Disorders revealed during brief neurological examination
• Dermal lesions at the site of stimulation (i.e. psoriasis, ulcera, infection)
• Pregnancy or breast feeding
• Subject currently has an active implantable device including ICD/pacemaker
• Exams/board reviews or other educational related obligations in the week of study sessions.
• Transmeridian travel within 1 month before the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Electrical Pain Detection Threshold (EPDT)<br /><br>EPDT (mA) (baseline)<br /><br>EPDT (mA) (NRS=0, 6, 10)<br /><br>EPDT (mA) (t = +1, 5, 10, 15min)<br /><br><br /><br>Pressure Pain Detection Threshold (N)<br /><br><br /><br>Cold Pressor Test:<br /><br>CPT (sec) (baseline)<br /><br>CPT (sec) (NRS=0, 6, 10)<br /><br>CPM (% EPDT) (NRS=0, 6, 10)<br /><br>CPM (% EPDT) (t = +1, 5, 10, 15min))</p><br>

Secondary Outcome Measures