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临床试验/NCT03467659
NCT03467659已完成不适用

Glycemic Response of Whole Grain Wheat Meals

Purdue University2 个研究点 分布在 1 个国家目标入组 16 人开始时间: 2017年2月16日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
16
试验地点
2
主要终点
Glycemic response

研究概览

简要总结

Whole grains have been associated with controlled glycemic response and increased satiety compared to refined grains. However, the properties of whole grains which are responsible for these purported improved health outcomes are still unclear. The current study investigated the extent of whole grains' low glycemic property when food properties are controlled, and how this relates to gastric emptying rate and glycemic response.

详细描述

It is generally assumed that whole grain foods confer a health benefit in regards to moderated glycemia and increased satiety compared to foods made from refined grains. However, the extent of whole grains' low glycemic property may be limited by certain factors. For example, physical properties such as viscosity or particle size and differing starch digestion rates of whole grain foods may strongly influence glycemic response and gastric emptying rate. In this study, whole and refined grain wheat porridges were prepared from materials originating from the same milling source, with matched pairs for viscosity, starch and dietary fiber contents, and particle size. Subjects consumed wheat porridges containing 13C-labeled octanoic acid for assessment of gastric emptying rate, and they wore a continuous glucose monitor for measuring postprandial glucose levels. The purpose of this research was to test the hypothesis that the purported moderated glycemic response and slow gastric emptying rate are dependent on how these foods are processed. This work highlights the need to consider specific properties of whole grain foods for desired health outcomes in order to optimize the design of whole grain-based foods.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Aged between 18-50 years old
  • Healthy, normal BMI (18.5 kg/m² <BMI < 25 kg/m²)
  • Be free of any gastrointestinal diseases, diabetes, cardiovascular diseases
  • Be free of any wheat allergies and gluten intolerances or sensitivities
  • Not be pregnant or nursing

排除标准

  • No medical problems
  • No medication
  • Pregnant or nursing

研究组 & 干预措施

Cracked whole wheat porridge

Experimental

Large particle whole wheat porridge

干预措施: Cracked whole wheat porridge (Other)

Semolina wheat porridge

Experimental

Large particle refined wheat porridge

干预措施: Semolina wheat porridge (Other)

Whole wheat flour porridge

Experimental

Small particle whole wheat porridge

干预措施: Whole wheat flour porridge (Other)

Refined wheat flour porridge

Experimental

Small particle refined wheat porridge

干预措施: Refined wheat flour porridge (Other)

Refined wheat flour porridge,fine bran

Experimental

Small particle refined wheat porridge with small particle bran

干预措施: Refined wheat flour porridge,fine bran (Other)

Refined wheat flour porridge,coarse bran

Experimental

Small particle refined wheat porridge with large particle bran

干预措施: Refined wheat flour porridge,coarse bran (Other)

结局指标

主要结局

Glycemic response

时间窗: Acute study, 4 hours measurement after consumption of test food

Blood glucose was measured using a continuous glucose monitor

Appetitive behavior

时间窗: Acute study, 4 hours measurement after consumption of test food.

Hunger and fullness scores using a 10 cm scale (0 = weakest feeling of hunger or fullness and 10 = highest feeling of hunger or fullness) will be taken after each meal.

Gastric emptying

时间窗: Acute study, 4 hours measurement after consumption of test food

Breath test was performed using 13C-octanoic acid mixed into test meals

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Bruce R. Hamaker

Professor

Purdue University

研究点 (2)

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