Flow versus Pressure Controlled Ventilation in patients with moderate to severe Acute Respiratory Distress Syndrome - FCV vs PCV in moderate to severe ARDS

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 28 人开始时间: 待定最近更新: 2024年5月6日

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all
•of the following criteria:
•- 18 years or older;
•- Provided written informed consent;
•- Undergoing controlled mechanical ventilation via an endotracheal tube;
•- Meeting all criteria of the Berlin definition of ARDS:
•o Hypoxic respiratory failure within 1 week of a known clinical insult or new
•or worsening respiratory symptoms
•o Bilateral opacities on X-ray or CT-scan not fully explained by effusions,
•lobar/lung collapse (atelectasis), or nodules
•o Respiratory failure not fully explained by cardiac failure or fluid overload.
•o Oxygenation: moderate ARDS P/F ratio between 101-200 mmHg, severe ARDS PF
•ratio <= 100mmHg, both with PEEP >= 5 cmH2O.
•- Development of ARDS <= 72 uur
•- Intubated

•- Severe sputum stasis or production requiring frequent bronchial suctioning
•(more than 5 times per nurse shift) - Untreated pneumothorax (i.e. no pleural
•drainage) - Hemodynamic instability defined as a mean arterial pressure below
•60mmHg not responding to fluids and/or vasopressors or a noradrenalin dose >
•0.5mcrg/kg/min - High (>15 mmHg) or instable (an increase in sedation or
•osmotherapy is required) intracranial pressure - An inner tube diameter of 6mm
•or less - Anticipating withdrawal of life support and/or shift to palliation as
•the goal of care - Inability to perform adequate electrical impedance
•tomography (EIT) measurements - Contra-indications for nasogastric tube or
•inability to perform adequate transpulmonary pressure measurements

发起方