Depression and Microbiota: Biological, and Psychological markers of treatment response

Recruiting

• Conditions: biologische markers; depression; Major depressive disorders; 10027946

• Registration Number: NL-OMON49635
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 350

Inclusion Criteria

Patient is eligble for participation when he/she: 1) will start neuromodulation
treatment or psychotherapy (behavioural activation) at the AMC, department of
Psychiatry, mood disorders; 2) has not started the treatment yet; 3) is
diagnosed with a unipolar depressive disorder; 4) is older than 18 years.

Exclusion Criteria

Co-morbid psychiatric disorders are accepted, except for schizophrenia,
psychosis, and unstable high risk patients with acute hightened risk of
suicide. If the main diagnosis of MDD is missing, the patient is not eligible.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome is the relationship between change in depressive<br /><br>symptomatology with change in microbioom compositions. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes are relationships between change in depressive symptoms and<br /><br>changes in other biological and psychological markers, including oral<br /><br>microbiota, blood serum, ecological momentary assessment, and psychological<br /><br>questionnaires.</p><br>