EUCTR2006-002098-30-NL进行中（未招募）不适用
Efficacy of Inhaled RhDNase in Mechanically Ventilated Pediatric Patients with an Atelectasis - RhDNase in ventilated pediatric patients
Erasmus Medical Centre Rotterdam0 个研究点目标入组 80 人开始时间: 2006年6月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •1. Age 0-18 years
- •2. Mechanical ventilation
- •3. Presence of an atelectasis on a chest radiograph (CXR)
- •4. First dose of study medication can be administered within 12 hours after an atelectasis has been diagnosed.
- •Are the trial subjects under 18? yes
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) no
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1. Children with neuromuscular disorders and impaired ability to cough; cardiomyopathy; or cystic fibrosis.
- •2. Post-gestational age < 32 weeks
- •3. Mechanical ventilation during muscle paralysis
- •4. Atelectasis due to a bronchoscopically diagnosed:
- •- foreign body aspiration
- •- tracheal or bronchial compression by lymph nodes or vessels
- •5. RhDNase treatment in the previous 48 hours.
- •6. Clinical condition or ventilator settings that are not compatible with nebulizing medication (according to the responsible physician)
- •7. Presence of a pneumothorax
研究者
相似试验
招募中
3 期
Efficacy of Inhaled RhDNase in Mechanically Ventilated Pediatric Patients with an Atelectasisatelectasispartly collapsed lung10024967NL-OMON30062Erasmus MC, Universitair Medisch Centrum Rotterdam80
已完成
不适用
Efficacy of Inhaled RhDNase in Mechanically Ventilated Pediatric Patients with an Atelectasis.Atelectasis during mechanical ventilation.NL-OMON21415Erasmus Medical Center, Sophia Children's Hospital. Dr. Molewaterplein 60, 3015 GJ Rotterdam80
进行中（未招募）
不适用
Efficacy of peripherally targeted inhaled rhDNase for persistent obstructive asthma in childhoodAsthma is a chronic inflammatory disorder in which many cells play a role, in particular mast cells, eosinophils and T lymphocytes. In susceptible individuals this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness and cough. These symptoms are usually associated with widespread but variable airflow limitation that is at least partly reversible either spontaneously or with treatment.MedDRA version: 8.1Level: LLTClassification code 10003553Term: AsthmaEUCTR2006-002337-20-NLErasmus Medical Centre Rotterdam60
已完成
不适用
Efficacy of peripherally targeted inhaled rhDNase for persistent obstructive asthma in childhoodObstructive pulmonary function, asthmaRespiratoryObstructive pulmonary disease, asthmaISRCTN71537084Erasmus Medical Center (The Netherlands)60
已完成
不适用
Efficacy of peripherally targeted inhaled rhDNase for persistent obstructive asthma in childhood.asthma with persistent obstructive pulmonary function.NL-OMON21320ErasmusMC Rotterdam60