Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Completed

• Conditions: Mechanical Ventilation Complication

• Registration Number: NCT04448782
• Lead Sponsor: Corporacion Parc Tauli

Brief Summary

Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-09
• Study First Submitted: 2020-06-17
• Study First Submitted QC: 2020-06-25
• Study First Posted: 2020-06-26
• Primary Completion: 2020-06-30
• Study Completion: 2020-06-30
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-13
• Last Update Posted: 2020-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator
• Diagnosis of COVID-19

Exclusion Criteria

• less than 48 hours of data,
• age < 18 years
• admitted from other centers under invasive mechanical ventilation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation	during the 5 first days of invasive mechanical ventilation	To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients

Secondary Outcome Measures

Name	Time	Method
Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation	From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation	To correlate the presence of Reverse Triggering with the level of sedation and use of neuromuscular blockers
Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation	Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days	To analyze the incidence of RT, ineffective efforts and double triggering throughout the period of invasive mechanical ventilation
Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation	From the day of mechanical ventilation initiation up to 5 days	To analyze the incidence of breath stacking and ineffective efforts secondary to RT.
Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation	Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days	To correlate the presence of asycnhronies and its type with duration of invasive mechanical ventilation, ICU length of stay and survival

Trial Locations

Locations (1)

Candelaria de Haro; 🇪🇸 Sabadell, Barcelona, Spain