Probiotics and Overreaching Recovery

Not Applicable

• Conditions: Fatigue; Muscle, Heart; Immunosuppression
• Interventions: Dietary Supplement: probiotics; Dietary Supplement: placebo

• Registration Number: NCT04885010
• Lead Sponsor: University of Padova

Brief Summary

Overloading is a key training principle used by athletes and coaches to improve physical performance. Intensified training periods are therefore commonly incorporated into the course of a regular training season. From a clinical point of view, very intense periods of training are associated with a temporary immunological deficiency which can lead to teh "overreaching syndroms".

During periods of overreaching, nutritional strategies are mainly aimed at ensuring sufficient amounts of energy to support the increase in effort. However less is known about nutritional supplements to attenuated the inflammatory/immunological response to training stress.

Probiotic bacteria are defined as live food ingredients beneficial to the host's health. Numerous health benefits have been attributed to probiotics, including effects on gastrointestinal tract function and disease, immune function, hyperlipidemia, hypertension, and allergic conditions. Studies in the literature on the ergogenic effect of probiotics in athletes are still scarce today. this study aims to explore the potential role of probiotics on performance, recovery from fatigue and immune function during intensive period of training.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-05
• Study First Submitted: 2021-05-07
• Study First Submitted QC: 2021-05-07
• Last Update Submitted: 2021-05-07
• Study First Posted: 2021-05-13
• Last Update Posted: 2021-05-13
• Study Start: 2021-06-01
• Primary Completion: 2021-09-30
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• age 25-55 years
• Body mass index:> 18 and <30 kg / m2
• Stable body weight for at least 3 months
• regular practice of physical activity for at least 2 years

Exclusion Criteria

• Chronic diseases (cardiovascular, hepatic, respiratory, cancer)
• Acute inflammatory states, infections or other pathologies
• Regular use of probiotics
• Use or treatment with steroids (within the previous 3 months)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Probiotics	probiotics	participants will train for 15 days while consuming the dietary supplement. During the last 8 days the intensity of training will increase to induce overreaching.
Placebo	placebo	participants will train for 15 days while consuming the dietary supplement. During the last 8 days the intensity of training will increase to induce overreaching.

Primary Outcome Measures

Name	Time	Method
lymphocyte subpopulation total T (CD3+)	Change from baseline to up to 15 days	lymphocyte subpopulation: total T (CD3+) %
T-helper (CD4+)	Change from baseline to up to 15 days	lymphocyte subpopulation: T-helper (CD4+) %
T-suppressor (CD8+)	Change from baseline to up to 15 days	lymphocyte subpopulation: T-suppressor (CD8+) %