General Anesthesia Using Remimazolam and Remifentanil Without Neuromuscular Blocking Agent: Prospective Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Remimazolam
- Conditions
- Myoma;Uterus
- Sponsor
- Seoul National University Bundang Hospital
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Remimazolam induction dose
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Remimazolam is a novel drug approved for induction and maintenance of general anesthesia. This study aims to check the appropriate dose and patient response by administering remimazolam and remifentanil in surgery that does not require a neuromuscular blocking agents.
Investigators
Hyo-Seok Na
Principal investigator
Seoul National University Bundang Hospital
Eligibility Criteria
Inclusion Criteria
- •Adult woman scheduled for gynecological surgery under general anesthesia
- •American Society of Anesthesiology grade 1 or 2
- •When using a laryngeal mask airway to maintain general anesthesia
Exclusion Criteria
- •Underlying diseases: liver, kidney, brain nervous system, glaucoma
- •Patients with BMI greater than 30 and less than 18.5
- •Patients diagnosed with sleep apnea
- •Alcohol or drug dependent patients
- •Patients with severe or acute respiratory failure
- •Lactose intolerance
- •Dextran 40 hypersensitivity
- •Patients in shock or coma
Arms & Interventions
General anesthesia using remimazolam and remifentanil
Adult female patients scheduled for gynecological surgery under general anesthesia using remimazolam and remifentanil
Intervention: Remimazolam
Outcomes
Primary Outcomes
Remimazolam induction dose
Time Frame: During the anesthesia induction (from initiation of anesthesia until the insertion of laryngeal mask airway)
Remimazolam maintenance dose
Time Frame: During the anesthesia maintenance (from the insertion of laryngeal mask airway until stopping remimazolam infusion)
Secondary Outcomes
- Use of rescue midazolam(During the anesthesia (from initiation of anesthesia until stopping remimazolam infusion))
- Use of rescue rocuronium(During the anesthesia (from initiation of anesthesia until stopping remimazolam infusion))
- Use of flumazenil(During the anesthesia recovery (from stopping remimazolam infusion until the recovery of consciousness))