Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)
- Conditions
- Depressive Disorder, Major
- Interventions
- Registration Number
- NCT02709746
- Lead Sponsor
- H. Lundbeck A/S
- Brief Summary
Evaluating the efficacy of vortioxetine 10 mg/day and 20 mg/day versus placebo on depressive symptoms in adolescents (age ≥12 and ≤17 years) with a DSM-5™ (Diagnostic and Statistical Manual of Mental Disorders, 5th edition) diagnosis of Major depressive disorder (MDD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 784
- The patient is a male or female, aged ≥12 and ≤17 years at Screening (patients who turn 18 years during the study will be allowed to continue in the study).
- The patient has Major depressive disorder (MDD), diagnosed according to DSM-5™.
- The patient has a Children Depression Rating Scale - Revised (CDRS-R) total score ≥45 at the Screening Visit and at the Baseline.
- The patient has a Clinical Global Impression - Severity of Illness (CGI-S) score ≥4 at the Screening Visit and at the Baseline
- The patient has provided assent to participation and parent(s)/legal representative (s) signed the Informed Consent Form.
- The patient has participated in a clinical study <30 days prior to the Screening Visit.
Other protocol defined inclusion and exclusion criteria may apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fluoxetine 20 mg/day, Fluoxetine 20 mg/day - Placebo Placebo - Vortioxetine 10 mg/day Vortioxetine 10 mg/day - Vortioxetine 20 mg/day Vortioxetine 20 mg/day -
- Primary Outcome Measures
Name Time Method Change in Children Depression Rating Scale - Revised (CDRS-R) Total Score After Treatment From Randomization to Week 8 The CDRS-R is a clinician-rated scale to measure the severity of depression of children and adolescents. The CDRS-R consists of 17 items: 14 items rate verbal observations, and three items rate nonverbal observations (tempo of language, hypoactivity, and nonverbal expression of depressed affect). Depression symptoms are rated on a 5-point scale from 1 to 5 for the verbal observations, and a 7-point scale from 1 to 7 for the nonverbal observations. The total score ranges from 17 (normal) to 113 (severe depression).
- Secondary Outcome Measures
Name Time Method Change in CDRS-R Total Score During Treatment (at Week 2) At week 2 The CDRS-R is a clinician-rated scale to measure the severity of depression of children and adolescents. The CDRS-R consists of 17 items: 14 items rate verbal observations, and three items rate nonverbal observations (tempo of language, hypoactivity, and nonverbal expression of depressed affect). Depression symptoms are rated on a 5-point scale from 1 to 5 for the verbal observations, and a 7-point scale from 1 to 7 for the nonverbal observations. The total score ranges from 17 (normal) to 113 (severe depression).Children and parents answer separately. Rater judges and selects 'Best'.
Change in CDRS-R Total Score During Treatment (at Week 4) At week 4 The CDRS-R is a clinician-rated scale to measure the severity of depression of children and adolescents. The CDRS-R consists of 17 items: 14 items rate verbal observations, and three items rate nonverbal observations (tempo of language, hypoactivity, and nonverbal expression of depressed affect). Depression symptoms are rated on a 5-point scale from 1 to 5 for the verbal observations, and a 7-point scale from 1 to 7 for the nonverbal observations. The total score ranges from 17 (normal) to 113 (severe depression).
Change in CDRS-R Total Score During Treatment (at Week 6) At week 6 The CDRS-R is a clinician-rated scale to measure the severity of depression of children and adolescents. The CDRS-R consists of 17 items: 14 items rate verbal observations, and three items rate nonverbal observations (tempo of language, hypoactivity, and nonverbal expression of depressed affect). Depression symptoms are rated on a 5-point scale from 1 to 5 for the verbal observations, and a 7-point scale from 1 to 7 for the nonverbal observations. The total score ranges from 17 (normal) to 113 (severe depression).
Change in CDRS-R Mood Score From randomization to Week 8 Change in Children Depression Rating Scale - Revised (CDRS-R) Mood. The CDRS-R has been widely used for the evaluation of children and adolescents with major depressive disorder (MDD). The CDRS-R total score is the sum of the responses to 17 items. Each item is graded on a 5- or 7-point scale. Mood is one of four subscores defined in the CDRS-R: sum of items 8, 11, 14, 15; score range 4 to 28. The highest possible score indicates the most severe measure of depression.
Change in CDRS-R Somatic Score From Randomization to Week 8 Change in Children Depression Rating Scale - Revised (CDRS-R): Somatic. The CDRS-R has been widely used for the evaluation of children and adolescents with major depressive disorder (MDD). The CDRS-R total score is the sum of the responses to 17 items. Each item is graded on a 5- or 7-point scale. Somatic is one of four subscores defined in the CDRS-R: sum of items 4, 5, 6, 7, 16, 17; score ranges from 6 to 36. The highest possible score indicates the most severe measure of depression.
Change in CDRS-R Subjective Score From Randomization to Week 8 Change in Children Depression Rating Scale - Revised (CDRS-R): Subjective. The CDRS-R has been widely used for the evaluation of children and adolescents with major depressive disorder (MDD). The CDRS-R total score is the sum of the responses to 17 items. Each item is graded on a 5- or 7-point scale. Subjective is one of four subscores defined in the CDRS-R: sum of items 9, 10, 12, 13; score ranges from 4 to 28. The highest possible score indicates the most severe measure of depression.
Change in CDRS-R Behaviour Score From Randomization to Week 8 Change in Children Depression Rating Scale - Revised (CDRS-R): Behaviour. The CDRS-R has been widely used for the evaluation of children and adolescents with major depressive disorder (MDD). The CDRS-R total score is the sum of the responses to 17 items. Each item is graded on a 5- or 7-point scale. behaviour is one of four subscores defined in the CDRS-R:sum of items 1, 2, 3; score ranges from 3 to 21. The highest possible score indicates the most severe measure of depression.
CDRS-R Response From Randomization to Week 8 Children Depression Rating Scale - Response: defined as a \>= 50% decrease in CDRS-R total score, calculated as (change from baseline \[Randomization\])/(baseline value - 17).
CDRS-R Remission From Randomization to Week 8 Remission is defined as a CDRS-R total score \<= 28.
Change in General Behaviour Inventory (GBI) Depression Sub Scale Score Assessed by the Parents From randomization to week 8 Using the 10-item depression subscale, assessed by parent (PGBI-10D). Change from randomization to Week 8 in GBI Total Parent/Guardian Version Depression score. GBI is a self-report inventory with 73 items focused on mood-related behaviors including depressive, hypomanic, and biphasic symptoms. One 20-item subscale completed by parent/guardian. Symptoms rated on 4-point Likert scale from 0 (never/hardly ever) to 3 (often/almost constantly). Minimum score 0=better outcome, maximum score 60=worse outcome.
Change General Behaviour Inventory (GBI) Depression Subscale Score Assessed by the Child From randomization to Week 8 The GBI 10-item mania scale is a parent- and subject-rated scale designed to screen for manic symptoms in children and adolescents. The 10 items are rated on a scale from 0 (never or hardly ever) to 3 (very often or almost constantly). The total score ranges from 0 to 30 points, with high scores indicating greater pathology.
Parent Global Assessment-Global Improvement (PGA) Score From Randomization to Week 8 The PGA is a parent-rated variation of the CGI-I to evaluate the severity of the child's symptoms. The PGA reflects assessments of change from Baseline symptoms using a 7 point scale ranging from 1 (very much improved) to 7 (very much worse).
Change in Symbol Digit Modalities Test (SDMT) From Randomization to Week 8 The Symbol Digit Modalities Test (SDMT) is a cognitive test designed to assess speed of performance requiring visual perception, spatial decision-making and psychomotor skills. The SDMT consists of 110 geometric symbols that the patient has to substitute with a corresponding digit in a 90-second period. Each correct digit is counted, and the total score ranges from 0 (less than normal functioning) to 110 (greater than normal functioning).
Change in Clinical Global Impression Severity of Illness (CGI-S) Score From Randomization to Week 8 The CGI-S provides the clinician's impression of the patient's current state of mental illness. The clinician uses his or her clinical experience of this patient population to rate the severity of the patient's current mental illness on a 7-point scale ranging from 1 (normal - not at all ill) to 7 (among the most extremely ill patients).
Clinical Global Impression - Global Improvement (CGI-I) Score From Randomization to Week 8 The CGI-I provides the clinician's impression of the patient's improvement (or worsening). The clinician assesses the patient's condition relative to a baseline on a 7-point scale ranging from 1 (very much improved) to 7 (very much worse). In all cases, the assessment should be made independent of whether the rater believes the improvement is drug-related or not.
CGI-S Remission From Randomization to Week 8 Remission defined as CGI-S score of 1 or 2.
Change in Children's Global Assessment Scale (CGAS) Score From Randomization to Week 8 The Children's Global Assessment Score (CGAS) is a rating scale which measures psychological, social and school functioning for children. The CGAS is a clinician-rated global scale to measure the lowest level of functioning for a child (4 to 16 years) during a specified time period. The CGAS contains behaviourally oriented descriptors at each anchor point that depict behaviours and life situations applicable to a child. The items range in value from 1 (most functionally impaired child) to 100 (the healthiest). A total score above 70 indicates normal function.
Change in Pediatric Quality of Life Inventory (PedsQL) Visual Analogue Scales (VAS): Afraid or Scared (Anxiety) Score From Randomization to Week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. A lower value represents a better outcome.
Change in PedsQL VAS: Sad or Blue (Sadness) Score From Randomization to Week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. A lower value represents a better outcome.
Change in PedsQL VAS: Angry Score From Randomization to Week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. A lower value represents a better outcome.
Change in PedsQL VAS: Worry Score From Randomization to Week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. A lower value represents a better outcome.
Change in PedsQL VAS: Tired (Fatigue) Score From Randomization to week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. A lower value represents a better outcome.
Change in PedsQL VAS: Pain or Hurt Score From Randomization to Week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. A lower value represents a better outcome.
Change in PedsQL VAS Total Average Score From Randomization to week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL™ VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue, and pain using visual analogue scales. The functionality for each domain is measured on a 10cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. The total score is the average of all 6 items. A lower value represents a better outcome.
Change in PedsQL Emotional Distress Summary Average Score From Randomization to week 8 The PedsQL™ VAS is designed to measure at-that-moment functioning in children and adolescents. The PedsQL VAS consists of 6 domains: anxiety, sadness, anger, worry, fatigue and pain using visual analogue scales. The functionality for each domain is measured on a 10 cm line with a happy face at one end and a sad face at the other (0-10 points). The patients are asked to mark on the line how they feel. The average emotional distress summary score is the mean of the anxiety, sadness, anger, and worry items. A lower value represents a better outcome.
Change in Paediatric Quality of Life Enjoyment and Satisfaction Questionnaire (PQ-LES-Q) Total Scores From Randomization to Week 8 PQ-LES-Q total score (items 1 to 14). The PQ-LES-Q is a patient-rated scale designed to assess satisfaction with life. It is an adaptation of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), which is used to measure quality of life in adults. The PQ LES Q consist of 15 items, item 1-14 assess the degree of satisfaction experienced by subjects in various areas of daily functioning (and item 15 allows subjects to summarize their experience in a global rating). Each item is rated on a 5-point scale from 1 (very poor) to 5 (very good). The total score range of item 1-14 (this outcome measurement) is 14 to 70, with higher scores indicating greater satisfaction.
Change in PQ-LES-Q Overall Score From Randomization to Week 8 PQ-LES-Q overall evaluation score (item 15). The PQ-LES-Q is a patient-rated scale designed to assess satisfaction with life. It is an adaptation of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), which is used to measure quality of life in adults. The PQ-LES-Q consist of 15 items, item 1-14 assess the degree of satisfaction experienced by subjects in various areas of daily functioning and item 15 allows subjects to summarize their experience in a global rating (this outcome measurement). Item 15 is rated on a 5-point scale from 1 (very poor) to 5 (very good).
Trial Locations
- Locations (124)
US1386
🇺🇸Wichita, Kansas, United States
CO1004
🇨🇴Bogotá, Colombia
CO1002
🇨🇴Pereira, Colombia
RU1059
🇷🇺Engel's, Russian Federation
RU1013
🇷🇺Saratov, Russian Federation
MX1023
🇲🇽Mazatlán, Mexico
EE1015
🇪🇪Viljandi, Estonia
PL1002
🇵🇱Bialystok, Poland
RU1009
🇷🇺Arkhangel'sk, Russian Federation
RU1016
🇷🇺Ekaterinburg, Russian Federation
RU1004
🇷🇺Nizhniy Novgorod, Russian Federation
UA1002
🇺🇦Kyiv, Ukraine
LV1008
🇱🇻Liepaja, Latvia
RU1010
🇷🇺Novosibirsk, Russian Federation
US1311
🇺🇸Naperville, Illinois, United States
US1309
🇺🇸Richmond, Virginia, United States
FR1041
🇫🇷Douai, France
US1315
🇺🇸Naperville, Illinois, United States
US1064
🇺🇸Creve Coeur, Missouri, United States
DE1076
🇩🇪Tübingen, Germany
IT1073
🇮🇹Genova, Italy
CA1038
🇨🇦Toronto, Canada
US1308
🇺🇸Orem, Utah, United States
MX1003
🇲🇽Ciudad de mexico, Mexico
US1229
🇺🇸Orange City, Florida, United States
MX1014
🇲🇽Culiacán, Mexico
US1114
🇺🇸Escondido, California, United States
US1266
🇺🇸Saint Charles, Missouri, United States
US1314
🇺🇸O'Fallon, Missouri, United States
EE1007
🇪🇪Tallinn, Estonia
HU1023
🇭🇺Budapest, Hungary
LV1002
🇱🇻Jelgava, Latvia
MX1011
🇲🇽Guadalajara, Mexico
MX1001
🇲🇽Nuevo León, Mexico
PL1068
🇵🇱Kielce, Poland
KR1038
🇰🇷Seoul, Korea, Republic of
ES1044
🇪🇸Madrid, Spain
US1171
🇺🇸Rochester, New York, United States
BG1023
🇧🇬Targovishte, Bulgaria
CO1001
🇨🇴Bello, Colombia
HU1020
🇭🇺Gyula, Hungary
IT1075
🇮🇹Cagliari, Italy
IT1074
🇮🇹Padova, Italy
RU1046
🇷🇺Krasnodar, Russian Federation
RU1011
🇷🇺Lipetsk, Russian Federation
IT1072 Osppedale Bambin gesu
🇮🇹Rome, Italy
LV1009
🇱🇻Riga, Latvia
MX1022
🇲🇽Guadalajara, Mexico
KR1032
🇰🇷Seoul, Korea, Republic of
PL1050
🇵🇱Gdansk, Poland
PL1052
🇵🇱Poznan, Poland
PL1051
🇵🇱Wroclaw, Poland
PL1057
🇵🇱Lublin, Poland
RS1011
🇷🇸Kragujevac, Serbia
GB1051
🇬🇧Glasgow, United Kingdom
RU1038
🇷🇺Saratov, Russian Federation
RU1057
🇷🇺Tomsk, Russian Federation
RU1048
🇷🇺Tonnel'nyy, Russian Federation
RS1010
🇷🇸Belgrad, Serbia
RS1003
🇷🇸Niš, Serbia
ES1040
🇪🇸Torremolinos, Spain
GB1047
🇬🇧Liverpool, United Kingdom
UA1001
🇺🇦Poltava, Ukraine
ES1041
🇪🇸Alcorcon, Spain
ES1043
🇪🇸Pamplona, Spain
UA1019
🇺🇦Odessa, Ukraine
UA1004
🇺🇦Ternopil', Ukraine
ZA1023
🇿🇦Sandton, South Africa
ES1018 Hospital de Sabadell
🇪🇸Sabadell, Spain
IT1068
🇮🇹Napoli, Italy
IT1070
🇮🇹Pisa, Italy
CA1036 University of Calgary
🇨🇦Calgary, Canada
BG1025
🇧🇬Varna, Bulgaria
US1333
🇺🇸Tucson, Arizona, United States
US1310
🇺🇸Little Rock, Arkansas, United States
US1387
🇺🇸Downey, California, United States
US1160 Renew Behavioral Health, Inc.
🇺🇸Long Beach, California, United States
US1370
🇺🇸Panorama City, California, United States
US1368
🇺🇸Orange, California, United States
US1133
🇺🇸Washington, District of Columbia, United States
US1103
🇺🇸Oak Brook, Illinois, United States
US1313
🇺🇸Marietta, Georgia, United States
US1261
🇺🇸Lake Charles, Louisiana, United States
US1385 Ericksen Research And Development
🇺🇸Clinton, Mississippi, United States
US1317
🇺🇸New York, New York, United States
US1334
🇺🇸Middleburg Heights, Ohio, United States
DE1081
🇩🇪Maulbronn, Germany
CO1003
🇨🇴Barranquilla, Colombia
DE1034
🇩🇪Mainz, Germany
DE1078
🇩🇪Freiburg, Germany
FR1017
🇫🇷Elancourt, France
FR1009
🇫🇷Nantes, France
DE1077
🇩🇪Mannheim, Germany
IT1029
🇮🇹Messina, Italy
KR1035
🇰🇷Cheonan, Korea, Republic of
UA1037
🇰🇷Gyeongsang, Korea, Republic of
LV1007
🇱🇻Sigulda, Latvia
MX1013
🇲🇽Guadalajara, Mexico
PL1054
🇵🇱Wąbrzeźno, Poland
RU1012
🇷🇺Rostov on Don, Russian Federation
RU1044
🇷🇺Rostov-na-Donu, Russian Federation
RS1006 Clinic of Neurology and Psychiatry for Children and Adolescents
🇷🇸Belgrade, Serbia
RU1030
🇷🇺St.Petersburg, Russian Federation
RS1007
🇷🇸Novi Sad, Serbia
ZA1019
🇿🇦Cape Town, South Africa
ZA1022
🇿🇦Randburg, South Africa
US1328
🇺🇸Austin, Texas, United States
US1320
🇺🇸Plano, Texas, United States
US1118
🇺🇸Glendale, California, United States
US1217
🇺🇸Gainesville, Florida, United States
US1351
🇺🇸Wildomar, California, United States
US1369
🇺🇸Dothan, Alabama, United States
US1062
🇺🇸Costa Mesa, California, United States
US1123
🇺🇸Imperial, California, United States
US1015
🇺🇸Baltimore, Maryland, United States
US1009
🇺🇸Atlanta, Georgia, United States
US1190
🇺🇸Staten Island, New York, United States
US1051
🇺🇸Cincinnati, Ohio, United States
US1312
🇺🇸Berlin, New Jersey, United States
US1222
🇺🇸Princeton, New Jersey, United States
US1054
🇺🇸Cleveland, Ohio, United States
US1323
🇺🇸Oklahoma City, Oklahoma, United States
US1329
🇺🇸Oklahoma City, Oklahoma, United States
US1162
🇺🇸San Antonio, Texas, United States