Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection
- Conditions
- ICU Patients Requiring a Central Venous Access
- Registration Number
- NCT00259350
- Lead Sponsor
- Poitiers University Hospital
- Brief Summary
The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions. No study has compare alcoholic formulations of low concentration of chlorhexidine and povidone iodine for skin disinfection prior to insertion of central venous catheters.
To compare the incidence of central venous catheter colonization after skin disinfection with either an alcoholic solution of povidone iodine or a combination of 0.5% chlorhexidine, 0.025% Benzalkonium and 4% benzylic alcohol.
To compare the incidence of catheter related bacteremia in the to study groups. To compare the local and general tolerance of the two antiseptic formulations
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 520
- Patients over 18 yeras of age
- Requiring an internal jugular or sub-clavian central venous catheter for their care during at least 72 h
- Informed consent signed up
- Bacteriemic infection not under control
- extensive cutaneous infection
- Women with childbearing potential
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Prevention of catheter colonization
- Secondary Outcome Measures
Name Time Method Prevention of catheter related bacteremia Prevention of a positive culture of the catheter whaterver the threshold Local and general tolerance
Trial Locations
- Locations (1)
University hospital
🇫🇷Poitiers, Vienne, France