Cardiovascular Imaging and Biomarker Analyses (CIBER)

• Conditions: Heart Failure; Coronary Artery Disease; Heart Diseases

• Registration Number: NCT03074253
• Lead Sponsor: Universitätsmedizin Mannheim

Brief Summary

"Cardiovascular Imaging and Biomarker Analyses (CIBER)" is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters.

Detailed Description

"Cardiovascular Imaging and Biomarker Analyses (CIBER)" is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters. Furthermore the prognostic value of biomarkers and imaging parameters on mid-term and long-term prognosis will be evaluated. Novel biomarkers will comprise blood derived biomarkers including neurohormones, proteins, cytokines, microRNAs and metabolomics.

Study Timeline

• Study Start: 2014-12-01
• Study First Submitted: 2017-03-03
• Study First Submitted QC: 2017-03-07
• Study First Posted: 2017-03-08
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-30
• Last Update Posted: 2019-10-31
• Primary Completion: 2020-07-01
• Study Completion: 2021-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• patients with low to intermediate risk for coronary artery disease

Exclusion Criteria

• under 18 years
• mechanical heart valve
• pulmonary embolism
• deep vein thrombosis
• myocardial infarction within the last 3 months
• electrical cardioversion within 30 days
• status after heart transplant
• transient ischemic attack (TIA) or stroke within last 30 days
• intracerebral bleeding within the last 2 months
• acute infection
• existing or planned pregnancy
• chronic kidney disease with eGFR < 40 ml/min

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biomarker levels before cardiac imaging	24 hours before cardiac imaging

Trial Locations

Locations (1)

First Department of Medicine, University Medical Centre Mannheim; 🇩🇪 Mannheim, Germany