Near to Infrared (NIR) Light Neuroprotection in Glaucomatous Optic Neuropathy
- Conditions
- Open Angle Glaucoma
- Registration Number
- NCT00844389
- Lead Sponsor
- Universidad de Valparaiso
- Brief Summary
The purpose of the study is to evaluate if near-to-infrared light stimulation can improve retinal ganglion cell function in glaucomatous patients.
- Detailed Description
Ganglion cell dysfunction in glaucomatous optic neuropathy has been ascribed to ganglion cell electrophysiological inactivation and to apoptotic cell death. Near-to-infrared light stimulation has been used to induce mitochondrial activation and to prevent apoptotic death through mitochondrial cytochrome oxidase c stimulation. Near-to-infrared light stimulation might be useful to induce ganglion cell activation and inhibit apoptotic cell death.
We propose that near-to-infrared light stimulation can be used as an adjuvant treatment combined with ocular hypotensive treatment in glaucomatous patients.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
- Clinical diagnose of Ocular Hypertension (cup to disk ratio 0,6 or less, normal Humphrey 24-2 visual field with aplanatic IOP over 21 mmHg) or Mild Glaucoma (cup to disk ratio 0,6 to 0,8, characteristic Humphrey 24-2 visual field defect PSD between 3 and 6 dB).
- Visual acuity 20/40 or better
- Diabetic retinopathy, Multiple Sclerosis, Parkinson disease
- Refractive error of 3 diopters or more
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pattern electroretinogram response Every two weeks for 4 months
- Secondary Outcome Measures
Name Time Method OCT ganglion cell layer average thickness, Visual Field defects Every month for four months
Trial Locations
- Locations (1)
Servicio de Oftalmología Hospital Van Buren
🇨🇱Valparaiso, Chile
Servicio de Oftalmología Hospital Van Buren🇨🇱Valparaiso, Chile