Acute Phase Reactions and Thrombophilia in Pediatric Patients With Migraine, Laboratory Investigations in Steady State and During Migraine Attack
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Proportion of patients with activation of the coagulation system.
研究概览
简要总结
Acute Migraine attacks can be related to vascular or coagulation activation. Previous studies found relative high incidence of prothrombotic events in Migraine. The present study intends to assess the coagulation system and activation in patients with Migraine during steady state phase and at the beginning of attacks and after 72 hours. A control group of patients with another acute neurologic event like convulsions will be also studied. Patients will be at pediatric age and teenagers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 5 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients at the pediatric age (5 to 20 ys old) suffering from Migraine attacks diagnosed by a neurologist.
排除标准
- •Patients with other underlying neurological conditions of coagulation diseases
研究组 & 干预措施
Patients during Migraine attacks
Patients with Migraine before, during and after Migraine attacks. Acute phase reaction profile, and activation of the coagulation system will be investigated together with thrombophilia profile.
干预措施: Laboratory tests (Other)
Control group
Patients with acute neurologic events like convulsions not related to fever or central nervous system (CNS) infections will be studied including acute phase reaction laboratory tests, thrombophilia and activation of the coagulation system
干预措施: Laboratory tests (Other)
结局指标
主要结局
Proportion of patients with activation of the coagulation system.
时间窗: Two years, each patient will be studied at attack onset and after 72 hours.
The further analysis will be performed in each patient: Pt, PTT, Platelets, Protein C, S, Antithrombin III, D Dimer, Factor VIII, Factor IX, Von Willebrand Factor and Prothrombin fragments I and II will be analyzed on day one of the crises, after 72 hours and in steady state.
次要结局
未报告次要终点
研究者
Dr Koren Ariel
Head of Pediatric Dpt B and Pediatric Hematology Unit
HaEmek Medical Center, Israel