Teriparatide for Improved Knee Prosthesis Fixation

Phase 2

Completed

• Conditions: Osteoarthritis of the Knee
• Interventions: Drug: teriparatide

• Registration Number: NCT01063504
• Lead Sponsor: University Hospital, Linkoeping

Brief Summary

The investigators will study how well knee joint prostheses become fixed to the bone when patients get teriparatide, compared to placebo. Measurements will use high resolution 3D radiography (radiostereometry, RSA).

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02
• Study First Submitted: 2010-02-04
• Study First Submitted QC: 2010-02-04
• Study First Posted: 2010-02-05
• Status Verified: 2013-06
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Last Update Submitted: 2013-06-17
• Last Update Posted: 2013-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Osteoarthritis of the knee planned for prosthesis surgery

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Exclusion Criteria

• Poor health, drugs affecting bone metabolism.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	teriparatide	-
Teriparatide 20 microgram daily for 2 months	teriparatide	-

Primary Outcome Measures

Name	Time	Method
Migration as measured by RSA maximal total point motion.	2 years

Trial Locations

Locations (1)

Motala hospital; 🇸🇪 Motala, Sweden