Improved Pain Management in Knee Osteoarthritis-related Surgeries

Completed

• Conditions: Pain Management; Knee Osteoarthritis; High Tibial Osteotomy; Unicompartmental Knee Arthroplasty; Total Knee Arthroplasty
• Interventions: Procedure: Preoperative pain managment; Procedure: Intraoperative pain managment; Procedure: Postoperative pain managment

• Registration Number: NCT06124170
• Lead Sponsor: Peng Liu

Brief Summary

In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.

Detailed Description

We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.

Study Timeline

• Study Start: 2016-03-01
• Primary Completion: 2022-03-02
• Study Completion: 2023-03-02
• Status Verified: 2023-11
• Study First Submitted: 2023-11-04
• Study First Submitted QC: 2023-11-08
• Last Update Submitted: 2023-11-08
• Study First Posted: 2023-11-09
• Last Update Posted: 2023-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 714

Inclusion Criteria

• first knee surgery were 50-80 years old had complete clinical and follow-up data

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Exclusion Criteria

• American Society of Anesthesiologists Physical Status grade≥4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Unicompartmental knee arthroplasty (UKA)	Preoperative pain managment	Unicompartmental knee arthroplasty
Unicompartmental knee arthroplasty (UKA)	Intraoperative pain managment	Unicompartmental knee arthroplasty
High tibial osteotomy (HTO)	Postoperative pain managment	High tibial osteotomy
Unicompartmental knee arthroplasty (UKA)	Postoperative pain managment	Unicompartmental knee arthroplasty
High tibial osteotomy (HTO)	Preoperative pain managment	High tibial osteotomy
High tibial osteotomy (HTO)	Intraoperative pain managment	High tibial osteotomy
Total knee arthroplasty (TKA)	Preoperative pain managment	Total knee arthroplasty
Total knee arthroplasty (TKA)	Intraoperative pain managment	Total knee arthroplasty
Total knee arthroplasty (TKA)	Postoperative pain managment	Total knee arthroplasty

Primary Outcome Measures

Name	Time	Method
visual analogue score (VAS)	72 hours after surgery	visual analogue score (VAS)

Secondary Outcome Measures

Name	Time	Method
Quadriceps muscle strength	72 hours after surgery	Quadriceps muscle strength
Scope of activities to knee joint	72 hours after surgery	Scope of activities to knee joint

Trial Locations

Locations (1)

Sichuan Provincial People's Hospital; 🇨🇳 Chengdu, Sichuan, China