Immune Score Based Radiomics in Nasopharyngeal Carcinoma (IMRAN Study)

Zhejiang Cancer Hospital5 sites in 1 country494 target enrollmentNovember 5, 2021

ConditionsNasopharyngeal Carcinoma

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Nasopharyngeal Carcinoma
Sponsor: Zhejiang Cancer Hospital
Enrollment: 494
Locations: 5
Primary Endpoint: Area Under Curve (AUC)
Status: Recruiting
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In nasopharyngeal carcinoma (NPC), tumor, node and metastasis (TNM) staging system is the main tool for determining treatment strategy and assessment of prognosis. However, the prognoses of patients with the same TNM stage after similar treatment vary widely. The aim of this study is to establish an immune score based radiomic staging system for NPC.

Registry

clinicaltrials.gov

Start Date

November 5, 2021

End Date

December 2027

Last Updated

4 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Zhejiang Cancer Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients with newly histologically confirmed non-keratinizing/keratinizing carcinoma.
•ECOG Performance status: 0-1 With normal liver function test (ALT, AST ≤2.5ULN) Renal: creatinine clearance ≥60ml/min Without hematopathy,marrow: WBC \>4\*109/L, HGB\>90G/L, and PLT\>100\*109/L. Written informed consent

Exclusion Criteria

•Contraindications for MRI scan Prior malignancy (except adequately treated carcinoma in-situ of the cervix or · basal/squamous cell carcinoma of the skin) Previous chemotherapy or radiotherapy (except non-melanomatous skin cancers outside the intended RT treatment volume) Patient is pregnant or lactating Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose \>1.5×ULN), or emotional disturbance.