Effect of Propolis Extract on Chronic Periodontitis Patients

Phase 3

• Conditions: Chronic periodontits.; chronic pericoronitis Periodontitis: NOS complex simplex

• Registration Number: IRCT2016122030475N3
• Lead Sponsor: Vice chancellor for research of International Campus, Tehran University of Medical Sienses.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Chronic periodontitis patients; The age range of 25 to 50 years; Having deep periodontal pockets (=5 mm) around a minimum of three teeth not adjacent to each other.
Exclusion criteria: Presence of periapical changes in the respective teeth; Systemic conditions requiring antibiotic prophylaxis or affecting the progression of disease or response to treatment; History of periodontal therapy in the past six months; Use of antibiotics, Anti-inflammatory drugs, anticonvulsants, immunosuppressive drugs or calcium channel blockers in the past three months; Pregnancy; Orthodontic treatment; Smoking; Having pacemaker; Mitral valve prolapse, Use of mouthrinses during treatment.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical Attachment level (CAL). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe.;Pocket Depth (PD). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe.;Bleeding on probing (BOP). Timepoint: Before intervention and one month later. Method of measurement: positive or negative, using periodontal probe.;Gingival index (GI). Timepoint: Before intervention and one month later. Method of measurement: Average number of teeth with positive bleeding on probing, using periodontal probe.;Matrix Metalloproteinase 8 level of saliva. Timepoint: Before intervention and one month later. Method of measurement: Pg/ml, ELISA TEST.