Study on the influence of cardiac output on blood concentration during continuous administration of fentanyl
Not Applicable
- Conditions
- Disease that is performed a free flap under general anesthesia
- Registration Number
- JPRN-UMIN000035777
- Lead Sponsor
- iigata University Medical & Dental Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1.Patient who did not obtain consent 2.Patients allergic to fentanyl 3.Patients with BMI> 30 4.Pregnant women / lactating women 5.Patients with liver failure / renal failure
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between the ratio or difference between blood concentration predicted by Shafer model and actual blood concentration of fentanyl and cardiac output or cardiac index
- Secondary Outcome Measures
Name Time Method Change of cardiac output using dopamine Change of concentration of fentanyl and its metabolites Measurement of activity of CYP3A (measurement of blood concentration of midazolam and metabolites)