Blood Pressure and Cardiac Output - the influence on cerebral perfusion during cardiopulmonary bypass.

Withdrawn

• Conditions: patienten aan de cardiopulmonale bypass; cerebral autoregulation; oxygen regulation of the brain

• Registration Number: NL-OMON40836
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

- age over 18 years
- undergoing cardiopulmonary bypass for Coronary Artery Bypass Grafting (CABG)/Valve replacement/repair
- having an appropriate temporal bone window for TransCranial Doppler monitoring

Exclusion Criteria

- requiring hypothermia during surgery
- requiring emergency surgery
- having a contraindication for phenylephrine
- having known brain pathology (e.g. Cerebral Vascular Accident (CVA) of increased intracranial pressure)
- having a history of severe carotid artery stenosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint is the cerebral perfusion measured by the regional cerebral<br /><br>oxygen saturation (rSO2) and the mean velocity of bloodflow in the middle<br /><br>cerebral artery (Vmca). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>