Mapping serotonergic activity after an oral challenge with the SSRI citalopram using pharmacologic Magnetic Resonance Imaging (phMRI)

Conditions: geen
none

Registration Number: NL-OMON32645

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

Male, 20-30 years old, right-handed, healthy

Exclusion Criteria

The presence of metal in the body (e.g. osteosynthetic material, pacemaker, artificial cardiac valves, dental braces) or other contraindications to MR imaging; claustrophobia; known or symptomatic brain disease, psychiatric or neurological disorders; current or previous treatment with medications that influence the 5-HT system (SSRIs, methylphenidate, sleep aids etc.); contraindications to citalopram treatment (known hypersensitivity to one of the contents, use of other SSRIs or pimozide (Orap), thioridazine or monoamine oxidase inhibitors (MAOI)); current or past drug (ab)use, excessive consumption of alcohol (>21 units/week), caffeine (> 8 cups/day) or nicotine (>10 cigarettes/day).

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Resting-state phMRI:<br /><br>- % change in resting-state fMRI signal compared to baseline in 5-HT related<br /><br>regions of interest (ROIs)<br /><br>Task-related phMRI:<br /><br>- % change in task-related fMRI signal from baseline in ROIs related to the<br /><br>specific tasks<br /><br><br /><br>- Differences in % change between resting-state and task-related phMRI scans,<br /><br>between ALS- and BOLD-based resting-state signal and between the four different<br /><br>task-related signals<br /><br>- Differences in % change between the citalopram-challenged phMRI scan sessions<br /><br>and the placebo scan session.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Test-retest ability: difference in % change between the two<br /><br>citalopram-challenged phMRI scan sessions<br /><br>- % change in cognitive performance on emotional face recognition task,<br /><br>Go/No-go task, reward task and motor task between the three different phMRI<br /><br>scan sessions and between the three baseline scan sessions (to exclude order<br /><br>effects)</p><br>