0.25% Levobupivacaine Versus 0.375% Ropivacaine: a Comparative Study in Ultrasound-Guided Infraclavicular Brachial Plexus Block
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- onset time of sensory block
研究概览
简要总结
Infraclavicular brachial plexus block has been used more frequently with the development of high-resolution ultrasound. Compared with peripheral nerve block using landmark technique or nerve stimulator technique, ultrasound-guided peripheral nerve block decreases the required dose of local anesthetics. As the dose of the drug used decreases, the systemic toxic effects of local anesthetics are reduced. However, the decreased dose of the drugs might have influence on the onset time of local anesthetics. Thus, the investigator aimed to evaluated the onset time of the two equipotent local anesthetics, 0.375% ropivacaine and 0.25% levobupivacaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status 1-3
- •Patients undergoing upper extremity surgery with infraclavicular brachial plexus block
排除标准
- •Patients who do not agree to participate in clinical trial
- •Patients presenting with neurological deficits of the upper arm, severe coagulopathy, chronic renal failure, cardiopulmonary compromise, cerebral vascular disease, hypersensitivity to hyaluronidase or local anesthetics or local infection at the site of the infraclavicular block, pregnancy
研究组 & 干预措施
Ropivacaine group
BPB with 0.375% ropivacaine solution
干预措施: Ropivacaine solution (Drug)
Levobupivacaine group
BPB with 0.25% levobupivacaine solution
干预措施: Levobupivacaine solution (Drug)
结局指标
主要结局
onset time of sensory block
时间窗: up to 40 minutes
sensory block of 4 nerves(radial, median, ulnar, musculocutaneous nerve) was assessed with pin-prick test every 5 minutes till 40 minutes from the completion of drug injection
次要结局
- duration of analgesia(24 hours)
- onset time of motor block(up to 40 minutes)
研究者
Hajung Kim
Clinical Instructor
Asan Medical Center