Uterine Lesions and Their Association to Invitro Fertilization(IVF) or Intracytoplasmic Sperm Injection(ICSI) Outcome
- Conditions
- IVF
- Interventions
- Procedure: IVF
- Registration Number
- NCT04939376
- Lead Sponsor
- Assiut University
- Brief Summary
1. To study the effect of uterine wall , intracavitary , cervical as well as cervical canal lesion on the outcome of IVF/ICSI cycle.
2. To establish a score for prediction of IVF/ICSI cycle success .
- Detailed Description
IVF is one of the most successful treatment of fertility, (1) however, several IVF cycles fail to achieve pregnancy (2).failure defined as three or more failed attempts of ICSI (3). Implantation failure is a complex in nature, may be due to structural or functional causes (3, 4).
that previously undiagnosed, misinterpreted initial diagnoses, or subtle newly added intrauterine abnormalities may be a significant cause of IVF failure (5, 6), studies say that intra-uterine pathologies represent 40-50 % of causes of ICSI failure (7, 8), hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum, or intrauterine adhesions could increase the pregnancy rate (9). so, Evaluation of the uterine cavity may become a routine investigation before assisted reproductive technology(ART) procedures (10).
In this study, we evaluate the relationship between the different uterine and cervical pathologies and decreased live birth rate.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 122
-
Women between 18 and 38 years old.
- An indication for IVF/ICSI..
- Women with BMI between 18.5 : 29.9 .
- Women with normal antimullerian hormone(AMH), antral follicle count(AFC) (good responders).
Refusal to join the study.
- Women with age less than 18 and more than 38 .
- Women with BMI less than 18.5 and more than 30 .
- Untreated tubal hydrosalpinges.
- Poor responders as assessed by AFC 4 or less ,AMH O.8 ng/dl (nice 2013).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group B IVF Matched women (eg. Age,parity, BMI, ovarian reserve....) with no uterine or ovarian abnormalities assessed by hysteroscopy or ultrasonography. Group A IVF Women with hysteroscopically or ultrasonographic detected uterine anomalies(adenomyosis,fibroid) intracavitary lesions ( like polyp, adhesion or septum) and those with detected endometrial abnormalities (like hypervascularization,pale endometrium) ,cervical lesion and cervical canal lesion or pelvic lesion
- Primary Outcome Measures
Name Time Method Pregnancy rate Baseline Pregnancy rate with IVF/ICSI with uterine lesions
- Secondary Outcome Measures
Name Time Method