Investigation of uterine (cervical, endometrial) carcinogenesis by identifying multiple interaction [Host – HPV – Microbiome – Environment]
- Conditions
- Neoplasms
- Registration Number
- KCT0002854
- Lead Sponsor
- CC Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 1800
1. Normal
1) 18 years of age or older
2) human papilloma virus(HPV)-negative women
3) had normal for final diagnosis
2. Cervix
1) 18 years of age or older with sexually active
2) human papilloma virus(HPV)-positive women
3) had normal or cervical intraepithelial neoplasia(CIN), cervical cancer
3. Endometrium
1) 18 years of age or older
2) women undergoing hysterectomy or curettage by any standard surgical approach
3) undergoing hysterectomy for benign disease, hyperplasia, or any stage of endometrial cancer
1. Normal
1) under 18 years
2) had normal for final diagnosis, but human papilloma virus(HPV)-positive women
3) no written informed consent
2. Cervix
1) under 18 years
2) women who were pregnant or nursing
3) had history of hysterectomy or treatment for cervical intraepithelial neoplasia(CIN) or cervical cancer during the 18 months previous to enrollment
4) no written informed consent
3. Endometrium
1) under 18 years
2) women who were pregnant or nursing
3) had taken antibiotics within two weeks preceding surgery
4) surgeon using morcellation during the hysterectomy procedure, due to the size of the uterus or for any other reason
5) no written informed consent
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association of dietary glycemic index(GI) with risk of cervical intraepithelial neoplasia(CIN) (odd ratio and 95% confidence interval);Association of dietary glycemic index(GI) with risk of cervical cancer (odd ratio and 95% confidence interval);Association of dietary glycemic load(GL) with risk of cervical intraepithelial neoplasia(CIN) (odd ratio and 95% confidence interval);Association of dietary glycemic load(GL) with risk of cervical cancer (odd ratio and 95% confidence interval)
- Secondary Outcome Measures
Name Time Method Association of human papillomavirus(HPV) infection with risk of cervical intraepithelial neoplasia(CIN) (odd ratio and 95% confidence interval);Association of human papillomavirus(HPV) infection with risk of cervical cancer (odd ratio and 95% confidence interval)