GABAergic modulation of alpha and gamma oscillations: implications for working memory maintenance

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

• Healthy volunteers between 18 and 35 years of age.
• Predominant right-handedness

Exclusion Criteria

• Abnormal hearing or (uncorrected) vision.
• Average use of more than 3 alcoholic beverages daily.
• History of prescribed medication within the month prior to the start of the study
• History of *over the counter* medication or cannabis usage within 2 months prior to the start of the study with exception of occasional use of paracetamol.
• History of drug (opiate, LSD, (meth)amphetamine, cocaine, solvents, cannabis, or barbiturate) or alcohol dependence.
• Average use of psychotropic medication or recreational drugs weekly or more.
• Habitual smoking, i.e. more than a pack of cigarettes per week and a self-reported inability or unease to cease smoking for 24 hours prior to testing.
• Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement.
• Regular use of corticosteroids.
• Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices).
• (History of) psychiatric treatment.
• (History of) neurological treatment.
• (History of) endocrine treatment.
• (History of) autonomic failure (e.g., vasovagal reflex syncope).
• (History of) clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic or pulmonary disease.
• (History of) epilepsy.
• (History of) Raynaud*s syndrome.
• Uncontrolled hypertension, defined as diastolic blood pressure at rest > 90 mmHg or systolic blood pressure at rest > 160 mmHg.
• Hypotension, defined as diastolic blood pressure < 60 mm Hg or systolic < 100 mm Hg or resting pulse rate < 50 beats/min.
• Glaucoma.
• Heart disease.
• Kidney disease.
• Liver disease.
• Lung/breathing problems.
• Sleep apnea.
• Muscle weakness.
• Current parodontitis.
• Diabetes.
• Family history of schizophrenia, bipolar disorder or major depressive disorder.
• Body Mass Index < 19 or > 30.
• Claustrophobia.
• Intense daily physical exercise.
• Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
• Possible pregnancy or breastfeeding.
• Increased risk for glaucoma.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Analysis of the oscillatory activity of alpha and gamma rhythms measured by MEG<br /><br>during the performance of the working memory task.</p><br>

Secondary Outcome Measures