“A comparative study of safety and efficacy of 0.5%Ropivacaine combined with either Dexmedetomidine orClonidine as adjuvant ; given as USG guidedsupraclavicular brachial plexus block, in patientsundergoing elective upper limb orthopaedic surgery.â€
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- 1. To compare the duration of analgesia,onset of sensory and motor block of
研究概览
简要总结
Post-operatively regional anaesthesia is of great value to treat pain following surgery and to minimize the use of opiods. Long acting local anaesthetic like Ropivacaine used for regional anaesthesia. Addition of an adjuvant to local anaesthetic can further have the advantage of prolonging the duration of block and post operative analgesia. In recent years supraclavicular brachial plexus block has gained popularity with addition of various adjuvant to anaesthetic solution. Present study we have taken two alpha receptor agonist Clonidin and Dexmeditomidine as adjuvant to Ropivacaine. We aim to discover which is more superior regarding safety and efficacy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 15.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I & II of body weight 30 to 80 kg, undergoing upperlimb orthopaedic surgery of less than two hours duration.
- •Free from any associated chronic systemic illness.
排除标准
- •Uncooperative patient Pregnant or lactating mother Neurological deficit in operative limb with chronic pain or on long term analgesics Patient having hypersensitivity or contraindication to Ropivacaine/ Dexmedetomidine/ Clonidine Local pathology at the site of injection All disability limiting the performance of block.
结局指标
主要结局
1. To compare the duration of analgesia,onset of sensory and motor block of
时间窗: Assessment of block quality by calculation of composite score of bromage scale and duration of analgesia was recorded by patient response.
0.5% Ropivacaine combined with either Dexmedetomidine or Clonidine
时间窗: Assessment of block quality by calculation of composite score of bromage scale and duration of analgesia was recorded by patient response.
3. Total dose of rescue medication consumption (tramadol and Diclofenac)
时间窗: Assessment of block quality by calculation of composite score of bromage scale and duration of analgesia was recorded by patient response.
in 24 hrs.
时间窗: Assessment of block quality by calculation of composite score of bromage scale and duration of analgesia was recorded by patient response.
as adjuvants injected perineurally.
时间窗: Assessment of block quality by calculation of composite score of bromage scale and duration of analgesia was recorded by patient response.
2. Number of Rescue analgesic given in 24 hours in both groups
时间窗: Assessment of block quality by calculation of composite score of bromage scale and duration of analgesia was recorded by patient response.
次要结局
- 1. NRS pain scores at rest (NRS-R) & at movement (passive/active) NRS-M(of operated upper limb in first 24 hours.)