Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- CPK levels
研究概览
简要总结
Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.
详细描述
During 2 months period all elligible patients undergoing knee artoplasty surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma CPK levels will be tested 3 times of all patients.(preoperative, postoperative 6th hour, postoperative 24th hour) this data will be recorded for 2 months. After this period of time data will be analysed and patients will be grouped according to the analgesic modalities used.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •knee artoplasty patients
- •under spinal anesthesia
排除标准
- •local anesthetic allergies
- •myopathies
- •coagulopathies
- •Obstructive sleep apne syndrome
- •hearth diseases
- •liver diseases
- •kidney diseases
- •thyroid-parathyriod dieseas
- •hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
- •pregnancy
结局指标
主要结局
CPK levels
时间窗: at postoperative 24th hour
Change from Baseline serum creatine phosphokinase at 24 hours
次要结局
- Number of patients requesting rescue analgesics(up to 24 hours)