CPK Levels After LC and Association With Analgesic Modalities

Recruiting

• Conditions: Myotoxicity
• Interventions: Other: Standart analgesia plan; Other: İnterfascial plane block

• Registration Number: NCT06508177
• Lead Sponsor: Samsun University

Brief Summary

Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

Detailed Description

During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Study Timeline

• Study First Submitted: 2024-07-12
• Study First Submitted QC: 2024-07-12
• Study First Posted: 2024-07-18
• Status Verified: 2024-08
• Study Start: 2024-08-05
• Last Update Submitted: 2024-08-05
• Last Update Posted: 2024-08-06
• Primary Completion: 2024-09-30
• Study Completion: 2024-10-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• ASA 1-3
• Laparoscopic cholecystectomy
• under General Anesthesia

Exclusion Criteria

• Morbidly obesity or cachexia
• local anesthetic allergies
• myopathies
• coagulopathies
• Obstructive sleep apne syndrome
• hearth diseases
• liver diseases
• kidney diseases
• thyroid-parathyriod dieseas
• hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Standart analgesia plan	Multimodal analgesia plans that does not include interfascial plane blocks
Interfascial plane blocks	İnterfascial plane block	Patients who are preferred to apply interfascial plane blocks as part of multimodal analgesia in the postoperative analgesia plan will be evaluated in this group.
Interfascial plane blocks	Standart analgesia plan	Patients who are preferred to apply interfascial plane blocks as part of multimodal analgesia in the postoperative analgesia plan will be evaluated in this group.

Primary Outcome Measures

Name	Time	Method
CPK levels	at postoperative 24th hour	Serum creatine phosphokinase levels at 24th hour

Trial Locations

Locations (1)

Samsun University; 🇹🇷 Samsun, Turkey