Does Postoperative Analgesic Modalities Effect Blood Creatin Phosphokinase Levels After Laparoscopic Cholecystectomy Surgery?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- CPK levels
研究概览
简要总结
Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.
详细描述
During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Laparoscopic cholecystectomy
- •under General Anesthesia
排除标准
- •Morbidly obesity or cachexia
- •local anesthetic allergies
- •myopathies
- •coagulopathies
- •Obstructive sleep apne syndrome
- •hearth diseases
- •liver diseases
- •kidney diseases
- •thyroid-parathyriod dieseas
- •hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
- •pregnancy
结局指标
主要结局
CPK levels
时间窗: at postoperative 24th hour
Serum creatine phosphokinase levels at 24th hour
次要结局
未报告次要终点