Does Incorporating Bone Mineral Density Change Fracture Risk Assessment and Influence Treatment Decisions in Rheumatoid Arthritis Patients?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Concordance Between FRAX Scores With and Without BMD
研究概览
简要总结
This study investigates whether incorporating bone mineral density (BMD) into FRAX calculations changes fracture risk assessment and influences treatment decisions in rheumatoid arthritis (RA) patients. Analyzing 60 RA patients, FRAX scores for 10-year major osteoporotic and hip fractures were calculated with and without BMD. While no significant differences were found between the two methods, discrepancies in treatment recommendations were identified, particularly for hip fractures. The findings emphasize the importance of combining BMD and FRAX for a more comprehensive fracture risk assessment and informed treatment decision-making in RA patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of rheumatoid arthritis (RA) based on ACR/EULAR criteria.
- •Age between 40-90 years.
- •Dual-energy X-ray absorptiometry (DXA) results obtained within the past six months.
- •Availability of complete clinical and demographic data for fracture risk assessment.
- •Patients who provide informed consent for the study.
排除标准
- •Patients with secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing's syndrome).
- •Use of medications affecting bone metabolism (e.g., glucocorticoids >7.5 mg/day, bisphosphonates, denosumab) within the past year.
- •History of metabolic bone diseases other than osteoporosis (e.g., osteomalacia, Paget's disease).
- •Patients with a history of malignancy, except for non-melanoma skin cancer.
- •Incomplete or missing data required for FRAX or DXA analysis.
- •Any condition or comorbidity likely to affect fracture risk assessment, as determined by the clinician.
结局指标
主要结局
Concordance Between FRAX Scores With and Without BMD
时间窗: 0 day
The agreement between 10-year fracture risk calculations for major osteoporotic fractures (MOF) and hip fractures (HF) using FRAX with and without bone mineral density (BMD).
次要结局
- Treatment Threshold Exceedance Based on FRAX Calculations(0 day)
研究者
Fatma Nur Kesiktaş
Principle Investigator
Istanbul Physical Medicine Rehabilitation Training and Research Hospital