The effect of low dose intravenous premedication (co-induction) on cardiac output and induction of anaesthesia

Phase 4

Completed

• Conditions: Anaesthetics; Cardiac output changes; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12610000447055
• Lead Sponsor: Christchurch Anaesthesia Education Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-06-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Surgery requiring insertion of arterial line,
American Society of Anesthetist (ASA) rating 1,2 or 3

Exclusion Criteria

Contra-indication to propofol.
Requirement for specific co-induction drug, other than study drug.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in cardiac output after coinduction as assessed by Vigileo ('Minimally Invasive, Arterial Pressure Cardiac Output Monitor'. utilising FloTrac sensor attatched to an Arterial Line).[Monitored continually from insertion of arterial line until induction/LOC.];Amount of induction drug required (as determined by time to LOC x infusion rate of 3ml/kg/hr) to loss of consciousness (LOC) as determined by:<br>1. Syringe drop and<br>2. Lack of response to command[Time to LOC measured from 'propofol on' time and determined by:<br>1. Syringe drop (primary indicator)<br>2. Lack of response to command (every 30 sec until lack of response)<br>Bi-Spectral Index monitor (BIS) 'below 60' time is also noted and amount of propofol till this point calculated as above.]

Secondary Outcome Measures

Name	Time	Method
il[Nil]