The differential effect of gastroesophageal reflux disease on laryngo-hypopharyngeal mechanosensitivity and chemosensitivity.

Not Applicable

Completed

• Conditions: Gastroesophageal Reflux; Laryngeal sensitivity; Respiratory - Other respiratory disorders / diseases; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12610000449033
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-06-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Presence of gastro-oesophageal reflux disease (GORD)

Exclusion Criteria

Significant preexisting pulmonary or laryngeal pathology
Prior Cerebrovascular accident

Eligible Participants will be deemed healthy apart from the presence of Gastro-oesophageal reflux disease.

Controls will all be deemed healthy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
aryngeal mechanosensitivity as measured by laryngeal adductor reflex (LAR)[% change in pressure required to elicit LAR (min 0.5mmHg)<br><br>This is measured immediately after the adminstration of air pressure];Laryngeal chemo-sensitivity as measure by volume of acid infused to elicit response[% change in volume of acid infused to elicit laryngeal response (min 0.1ml)<br><br>This is measured immediately after adminsitration of acid]

Secondary Outcome Measures

Name	Time	Method
Correlation between changes in mechano and chemo-sensitivity responses in controls and patients with Gastro-oesophageal Reflux Disease (GORD).[Linear correlation bewteen mechano and chemo responses in patients and controls. This is performed immediately after stimulation with both air pressure and acid.]