Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study

Not yet recruiting

• Conditions: Intracranial Atherosclerosis; Stroke, Ischemic; Posterior Circulation Brain Infarction
• Interventions: Other: we are aiming to develop a Scoring system based on certain variables derived from both groups

• Registration Number: NCT06453252
• Lead Sponsor: Sohag University

Brief Summary

Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT). The aim of the study is to develop and validate a scoring system for pre-thrombectomy diagnosis of ICAD in posterior circulation large vessel/distal medium vessel occlusion strokes (LVOs/DMVOs).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-06-05
• Study First Submitted QC: 2024-06-05
• Study First Posted: 2024-06-11
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-09
• Last Update Posted: 2024-07-10
• Study Start: 2024-08-01
• Primary Completion: 2025-06-01
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Adult ≥18 years
2. Patient with posterior circulation strokes who underwent mechanical thrombectomy.

Exclusion Criteria

1. Patients with anterior circulation stroke.
2. Patients with intracranial hemorrhage
3. Patients without baseline radiological data.
4. Extracranial large vessel atherosclerosis related strokes.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-ICAD cases (controls)	we are aiming to develop a Scoring system based on certain variables derived from both groups	Non-ICAD cases (controls) includes patients with posterior circulation stroke attributed to stroke etiologies other than ICAD.
ICAD group	we are aiming to develop a Scoring system based on certain variables derived from both groups	includes ICAD-related stroke made when a smooth-bordered lesions leading to delayed perfusion on conventional-angiography (without competing stroke etiology) or when irregular-surfaced lesions involving the target vessel during mechanical thrombectomy were unveiled (with or without competing stroke etiology).

Primary Outcome Measures

Name	Time	Method
Post-procedural outcomes included any intracranial hemorrhage, symptomatic ICH (sICH)	June 1st, 2025	sICH is defined as local or remote parenchymal hemorrhage type 2, subarachnoid hemorrhage, and/or intraventricular hemorrhage, combined with a neurological deterioration of 4 points or more on the NIHSS from baseline or leading to death that the physician judged was causative of the deterioration) per ECASS III criteria

Secondary Outcome Measures

Name	Time	Method
90 day modified Rankin scale (mRS)	June 1st, 2025	a score of 0 to 4 on the modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 4 moderately severe disability, and 6 death) at 90 days, was changed to a good functional status (a modified Rankin scale score of 0 to 3, with a score of 3 indicating moderate disability)
90 day mortality	June 1st, 2025

Trial Locations

Locations (2)

Marcus stroke and neuroscience center, Grady Memorial Hospital; 🇺🇸 Atlanta, Georgia, United States

Sohag university hospitals; 🇪🇬 Sohag, Egypt