JPRN-UMIN000040163
Completed
未知
Study for the pathogenesis of eosinophilic polyangiitis granulomatosis (EGPA) - Study for the pathogenesis of eosinophilic polyangiitis granulomatosis (EGPA)
ational Hospital Organization Sagamihara National Hospital0 sites100 target enrollmentApril 20, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Eosinophilic granulomatosis with polyangiitis
- Sponsor
- ational Hospital Organization Sagamihara National Hospital
- Enrollment
- 100
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
In active EGPA, 33 proteins, mainly related to eosinophils, type 2 inflammation, and cell adhesion factors, were elevated compared to asthma. In contrast, 12 proteins were decreased with steroid treatment. Fifty-nine proteins, including functional proteins involved in cell proliferation, angiogenesis, and type 3 inflammation as well as eosinophilic inflammation, were altered by the additional administration of mepolizumab. MicroRNA coverage analysis showed 8 significantly different between EGPA and asthma.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Individuals who are judged to be ineligible by the study representative or the treating physician
Outcomes
Primary Outcomes
Not specified
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