JPRN-UMIN000040163已完成未知
Study for the pathogenesis of eosinophilic polyangiitis granulomatosis (EGPA) - Study for the pathogenesis of eosinophilic polyangiitis granulomatosis (EGPA)
ational Hospital Organization Sagamihara National Hospital0 个研究点目标入组 100 人开始时间: 2020年4月20日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 100
研究概览
简要总结
In active EGPA, 33 proteins, mainly related to eosinophils, type 2 inflammation, and cell adhesion factors, were elevated compared to asthma. In contrast, 12 proteins were decreased with steroid treatment. Fifty-nine proteins, including functional proteins involved in cell proliferation, angiogenesis, and type 3 inflammation as well as eosinophilic inflammation, were altered by the additional administration of mepolizumab. MicroRNA coverage analysis showed 8 significantly different between EGPA and asthma.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 80years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •Individuals who are judged to be ineligible by the study representative or the treating physician
研究者
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