Comparison Between Different Ventilator Hyperinflation Maneuvers
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Infections, Respiratory
- 发起方
- Brazilian Institute of Higher Education of Censa
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Peak Expiratory Flow
- 状态
- 已完成
- 最后更新
- 7年前
概览
简要总结
The hyperinflation ventilator was performed in different modalities and ventilatory adjustments, with total pressure of 40cmH2O. The inspiratory volume, inspiratory time, mean airway pressure, inspiratory and expiratory flow, and bias flow were evaluated.
详细描述
PURPOSE: To compare different ways of applying ventilator hyperinflation. METHODS: A randomized crossover clinical trial was performed with 30 patients (66.5 ± 17.3 years) with hypersecretion. The ventilator hyperinflation was performed in five ventilatory modalities for five minutes, with an interval of 2 hours, the order being determined by randomization: controlled ventilation at volume (VCV) with constant flow of 20 (VCV20) Lpm and 40 Lpm (VCV40), controlled ventilation pressure ventilation (PCV), controlled pressure ventilation associated with inspiratory time adjustment (PCV + Tins) and support pressure ventilation (PSV). In VCV mode, the volume was increased every 50mL, until reaching a maximum pressure of 40cmH2O. In the pressure controlled modes, the inspiratory pressure was increased every 5 cmH2O until the total pressure reached 40 cmH2O. The inspiratory time was adjusted so that the inspiratory flow reached the baseline. The following variables were evaluated: tidal volume, inspiratory time (Tins), mean airway pressure (Pmean), peak inspiratory flow (PIFR) and expiratory flow (PEFR), PIFR / PEFR and Bias Flow (PEFR-PIFR).
研究者
Luciano Matos Chicayban
Principal Investigator
Brazilian Institute of Higher Education of Censa
入排标准
入选标准
- •Pulmonary infection
- •Mechanically ventilated for more than 96 hours through pressure-assisted ventilation (PSV) or pressure-controlled ventilation (PCV)
- •Static compliance between 30 and 70 mL/cmH2O
- •PEEP between 5 and 8 cmH2O.
排除标准
- •Hemodynamic instability
- •Non-drained pleural effusion or pneumothorax
- •Intracranial hypertension
- •Bronchospasm
- •Adult respiratory distress syndrome (ARDS)
- •Decompensated congestive heart failure
结局指标
主要结局
Peak Expiratory Flow
时间窗: Five minutes after the onset of intervention
maximal expiratory flow in 2 cycles
PIFR/PEFR
时间窗: Five minutes after the onset of intervention
Peak inspiratory to expiratory flow ratio
Bias Flow
时间窗: Five minutes after the onset of intervention
Difference between peak inspiratory and expiratory flows
Inspiratory Volume
时间窗: Five minutes after the onset of intervention
Inspiratory volume reached in each mode of ventilator hyperinflation, under a maximum pressure of 40cmH2O
Mean Pressure
时间窗: Five minutes after the onset of intervention
airway mean pressure measured on the mechanical ventilator in 2 cycles
Peak Inspiratory Flow
时间窗: Five minutes after the onset of intervention
Maximal inspiratory flow in 2 cycles
Inspiratory time
时间窗: Five minutes after the onset of intervention
inspiratory time necessary for the inspiratory flow to reach the baseline or according to the settings of each modality