Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
- Registration Number
- NCT04704271
- Lead Sponsor
- Yale University
- Brief Summary
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
- Detailed Description
To characterize the acute effects of vaporized THC in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- At least one lifetime exposure to cannabis
- Good physical and mental health
Read More
Exclusion Criteria
- Cannabis naïve individuals
- Major current or recent stressors
Read More
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Delta-9-Tetrahydrocannabinol (THC) Inhaled THC 4 mg vaporized THC will be administered. Placebo Placebo Inhaled placebo (no active cannabinoids)
- Primary Outcome Measures
Name Time Method Change from Baseline: Rewarding Effects measured by Visual Analog Scale (VAS) Changes in "high" assessed over the following timepoints: baseline, +60, +80, +120, +180, +300 minutes after start of oral Dronabinol administration. Subjective measure of THC induced "high"
Change from Baseline: Verbal Learning: Measured by Rey Auditory Verbal Learning Test (RAVLT) Baseline and +80 minutes after start of oral Dronabinol administration. Measured as delay recall on the AVLT
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
🇺🇸West Haven, Connecticut, United States