Evaluation of the bioavailability of bioactive wheat bran components from bread rolls
Not Applicable
Completed
- Conditions
- Chronic diseases, particularly cardiovascular disease and cancersNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN27269236
- Lead Sponsor
- European Commission (Belgium)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
Healthy 18 - 40 year old men and women with Body Mass Index (BMI) between 18 and 30 kg/m^2.
Exclusion Criteria
1. Smokers
2. Individuals with diabetes
3. Pre-existing chronic disease
4. On any prescription medicine
5. Individuals who regularly take any vitamin or mineral supplement or did so in the 6 months prior to the study
6. Gluten or wheat intolerant individuals
7. Pregnant or lactating women
8. Individuals who have given blood to the Blood Transfusion Service (BTS) in the 4 months prior to the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Changes in plasma betaine, choline, folate, tocopherols and ferulic acid attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours and 3 hours post-meal<br>2. Changes in urinary ferulic acid attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours, 3 hours and 4 hours post-meal
- Secondary Outcome Measures
Name Time Method 1. Changes in plasma antioxidant activity attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours and 3 hours post-meal<br>2. Changes in urinary antioxidant activity and phenolic activity attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours, 3 hours and 4 hours post-meal<br>3. Evaluation of the effects of processing, including iron fortification, on the availability of the bioactive components in wheat fractions, using test-meal 2 and comparisons with previous work