Assessment of the bioavailability of phenolics from an orange peel extract
- Conditions
- geen aandoening, het onderzoek is gericht op biobeschikbaarheidbioavailability
- Registration Number
- NL-OMON39992
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Age 18-75y, generally healthy (i.e. no severe conditions based on medical assessment), non-smoking
Exclusion Criteria
current pregnancy, extreme BMI (<18,5 or >25), clinically significant abnormal liver functioning, blood donation during the last 4 weeks prior to the first dosing
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary aim of the study is to evaluate the bioavailability of hesperidin,<br /><br>the main flavonoid present in the orange peel extract, which was previously<br /><br>shown to have biological activity. Assessment and evaluation will be done by<br /><br>analyzing the plasma and urinary concentrations of the main study parameter:<br /><br>hesperidin and hesperitin in plasma and urine following a single oral<br /><br>consumption of the respective compositions and dosage forms. The main endpoint<br /><br>is the determination of the most effective dosage form of hesperidin. To do<br /><br>this, blood samples will be collected pre-dose and after 5, 15, 30 min, 1, 2,<br /><br>3, 4, 6, 8, 10 and 24 h. Urine will be collected and pooled during the same<br /><br>time period.</p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>