Effects of resistance training or NMES in COPD.

Conditions: Chronic Obstructive Pulmonary Disease (COPD)Chronische obstructieve longaandoeningen (COPD)

Lead Sponsor: Ciro, centre of expertise for chronic organ failure Hornerheide 1, 6085 NM Horn, the NetherlandsI www.ciro-horn.nl

Brief Summary: 1. Sillen MJ, Janssen PP, Akkermans MA, Wouters EF, Spruit MA. The metabolic response during resistance training and neuromuscular electrical stimulation (NMES) in patients with COPD, a pilot study. Respir Med 2008 May;102(5):786-9 .<br> 2. Sillen MJ, Speksnijder CM, Eterman RM, Janssen PP, Wagers SS, Wouters EF, Uszko-Lencer HM, Spruit MA. Effects of neuromuscular electrical stimulation of muscles of ambulation in patients with chronic heart failure or COPD: A systematic review of the English-language Literature. Chest 2009 Apr; 136(4):44-61.<br> 3. Sillen MJ, Wouters EF, Franssen FME, Spruit MA. Resistance training and neuromuscular electrical stimulation during acute exacerbations of chronic obstructive pulmonary disease. Int J Respir Care 2009 May; 5(1): 14-16.<br> 4. Sillen MJ, Wouters EF, Franssen FME, Meijer K, Stakenborg KHP, Spruit MA. Oxygen uptake and ventilation during high-frequency versus low-frequency neuromuscular electrical stimulation in COPD, a pilot study. Submitted.

Recruitment & Eligibility

Inclusion Criteria

1. Primary diagnosis of COPD;

2. No acute COPD exacerbations in the past 4 weeks;

Exclusion Criteria

1. Neuromuscular diseases;

2. Joint disorders in hip, leg and/or knee;

Primary Outcome Measures

Name	Time	Method
Quadriceps muscle function: Peak strength and endurance.

Secondary Outcome Measures

Name	Time	Method
1. Health status (St. George's Respiratory Questionnaire, SGRQ);<br /><br>2. Functional exercise capacity (6-minute walking test, 6MWT);<br /><br>3. Exercise tolerance (constant work-rate cycling endurance test);<br /><br>4. Body composition (body mass index, fat free mass index) (whole-body dual-energy x-ray absorptiometry scan, DEXA scan);<br /><br>5. Dyspnoea (MRC dyspnoea scale);<br /><br>6. Metabolic load (oxygen uptake and ventilation) (Oxycon Mobile, VIASYS Healthcare,the Netherlands);<br /><br>7. Changes in vastus lateralis fiber type shift, fiber cross sectional area and enzyme activity (muscle biopsy).