Diabetes Resistance Training Adaptations in Elderly
- Conditions
- Diabetes Mellitus, Type 2
- Registration Number
- NCT02548000
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Brief Summary
This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2. Half of participants will be the intervention group that will perform resistance training, while the other half will be the control group that will perform stretching sessions.
- Detailed Description
Resistance training may be an interesting strategy to fight diabetes deleterious conditions, as it is known to increase muscle mass and quality, strength, functional capacity, vascular health, and decrease inflammation status and blood lipids, besides leading to improves in glycemic control. To test this hypothesis, 42 diabetic patients will be recruited and randomized to two groups that will be evaluated before and after 12 weeks of both intervention or control period. The resistance training group will perform all body resistance exercises three times per week, while the control group will perform a stretching session one time per week.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Type 2 diabetes
- 60 yers and older
- HbA1c > 6,5%
- BMI from 18,5 kg/m2 - 34,9 kg/m2
- Current smoking
- Insulin users
- Hypertension uncontrolled
- Diabetic neuropathy
- Diabetic retinopathy
- Diabetic nephropathy
- Peripheral amputations
- Clinical depression
- Myocardial infarction (within past 6 months)
- Any unstable chronic condition
- Muscle-skeletal complications that limit the practice of the exercises
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Quadriceps Muscle Quality measure by echo intensity 12 weeks Echo intensity is a grey scale for analyse the image that ranging from 0 (black) to 255 (white).
- Secondary Outcome Measures
Name Time Method Functional capacity measure by stair climb test. 12 weeks Total time, as fast as possible, to climb 10 steps.
Glycemic profile 12 weeks Blood glycated hemoglobin and glucose will be measured in a regular laboratorial equipment (COBAS C111)
Functional capacity measure by sit-to-stand-up test 12 weeks The time, as fast as possible, to stand and sit on the chair 10 times.
Muscle thickness measured by ultrasonography 12 weeks Muscle thickness measured by ultrasonography takes into account the superior fascia of the muscle and the distance until the inferior fascia. It is reported in mm.
Lipid profile 12 weeks HDL, LDL, total cholesterol and triglycerides will be measured in a regular laboratorial equipment (COBAS C111)
Quadriceps Muscle Quality measure by specific tension 12 weeks Specific tension is the ratio between muscle strength and muscle mass.
Functional capacity measure by time up and go test 12 weeks Time to get up from the chair walk around the marker (3 m) and return to the sitting position, as fast as possible.
Quadriceps muscle power capacity measure by rate of torque development. 12 weeks The rate torque development is a slope of torque/time curve.
Inflammation status estimated by tumor necrosis factor alpha (TNF-α ) and C reactive protein (CRP) 12 weeks TNF-α will be evaluated by specific commercial kit and CRP will be measured in a regular laboratorial equipment (COBAS C111).
Endothelial function measured by ultrasonography 12 weeks Endothelial function estimated by the response of endothelial cells for hyperemia.
Quadriceps muscle strength measured by one repetition maximum (1RM) test. 12 weeks 1RM is a maximum load lifted, reported in kg, during the knee extension.
Visceral adipose tissue measured by ultrasonography 12 weks Visceral adipose tissue (VAT) thickness measured by ultrasonography. The VAT thickness is considered from the back of the subcutaneous tissue until the anterior part of the aorta. It is reported in mm.
Trial Locations
- Locations (2)
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande do Sul, Brazil
Federal University of Rio Grande do Sul, Physical Education School
🇧🇷Porto Alegre, Rio Grande do Sul, Brazil
Hospital de Clinicas de Porto Alegre🇧🇷Porto Alegre, Rio Grande do Sul, Brazil