Muscle and Vascular Adaptations Induced by Resistance Training in Elderly Diabetic Type 2
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- Quadriceps Muscle Quality measure by echo intensity
研究概览
简要总结
This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2. Half of participants will be the intervention group that will perform resistance training, while the other half will be the control group that will perform stretching sessions.
详细描述
Resistance training may be an interesting strategy to fight diabetes deleterious conditions, as it is known to increase muscle mass and quality, strength, functional capacity, vascular health, and decrease inflammation status and blood lipids, besides leading to improves in glycemic control. To test this hypothesis, 42 diabetic patients will be recruited and randomized to two groups that will be evaluated before and after 12 weeks of both intervention or control period. The resistance training group will perform all body resistance exercises three times per week, while the control group will perform a stretching session one time per week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes
- •60 yers and older
- •HbA1c > 6,5%
- •BMI from 18,5 kg/m2 - 34,9 kg/m2
排除标准
- •Current smoking
- •Insulin users
- •Hypertension uncontrolled
- •Diabetic neuropathy
- •Diabetic retinopathy
- •Diabetic nephropathy
- •Peripheral amputations
- •Clinical depression
- •Myocardial infarction (within past 6 months)
- •Any unstable chronic condition
- •Muscle-skeletal complications that limit the practice of the exercises
研究组 & 干预措施
Resistance training
Resistance training will be performed three times a week, for 12 weeks, composed by 12 resistance exercises for all body muscles with 2-3 series and 12-8 repetitions in each exercise.
干预措施: Resistance training (Other)
Stretching control
The control group will perform one stretching session a week.
干预措施: Stretching control (Other)
结局指标
主要结局
Quadriceps Muscle Quality measure by echo intensity
时间窗: 12 weeks
Echo intensity is a grey scale for analyse the image that ranging from 0 (black) to 255 (white).
次要结局
- Functional capacity measure by stair climb test.(12 weeks)
- Glycemic profile(12 weeks)
- Functional capacity measure by sit-to-stand-up test(12 weeks)
- Muscle thickness measured by ultrasonography(12 weeks)
- Lipid profile(12 weeks)
- Quadriceps Muscle Quality measure by specific tension(12 weeks)
- Functional capacity measure by time up and go test(12 weeks)
- Quadriceps muscle power capacity measure by rate of torque development.(12 weeks)
- Inflammation status estimated by tumor necrosis factor alpha (TNF-α ) and C reactive protein (CRP)(12 weeks)
- Endothelial function measured by ultrasonography(12 weeks)
- Quadriceps muscle strength measured by one repetition maximum (1RM) test.(12 weeks)
- Visceral adipose tissue measured by ultrasonography(12 weks)