Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients

University of Pernambuco1 site in 1 country30 target enrollmentJanuary 2010

ConditionsPeripheral Artery Disease Intermittent Claudication

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Peripheral Artery Disease
Sponsor: University of Pernambuco
Enrollment: 30
Locations: 1
Primary Endpoint: Change in blood pressure
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study was to analyze the effects of resistance exercise and training on cardiovascular function of peripheral artery disease patients.

Detailed Description

Several studies have shown that strength training can promote important benefits for the cardiovascular system in healthy subjects and patients with chronic diseases. However, the effects of resistance exercise on cardiovascular function in intermittent claudication patients are unclear. In addition, it also do not know the chronic effects on cardiovascular function in these patients.

Registry

clinicaltrials.gov

Start Date

January 2010

End Date

December 2015

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Pernambuco

Responsible Party

Principal Investigator

Raphael M. Ritti Dias

Full Professor

University of Pernambuco

Eligibility Criteria

Inclusion Criteria

•Had a graded treadmill test that was limited by claudication (2 minutes)
•Had an ankle brachial index \<0.90
•Had systolic blood pressure ,160 mmHg and/or diastolic blood pressure,105 mmHg
•Were not performing any regular exercise program
•Were not using antihypertensive medications affecting the heart rate (e.g., b-blockers and nondihydropyridine calcium channel blockers)
•Were nonobese
•Individuals who have not undergone bypass surgery or angioplasty least one year ago

Exclusion Criteria

•Had no symptoms related to myocardial ischemia during the treadmill test
•Amputation

Outcomes

Primary Outcomes

Change in blood pressure

Time Frame: Change from baseline to 12 and 24 weeks

Secondary Outcomes

Change in Health related Quality of life(Change from baseline to 12 and 24 weeksBaseline, 12 wks and 24 wks)
Change Serum Cholesterol(Change from baseline to 12 and 24 weeks)
Change in body fat(Change from baseline to 12 and 24 weeks)
Change in serum glucose(Change from baseline to 12 and 24 weeks)
Change in Walking distance(Change from baseline to 12 and 24 weeks)
Change in Muscle blood flow of limbs(Change from baseline to 12 and 24 weeks)
Change in TNFalpha(Change from baseline to 12 and 24 weeks)
Change in Score Short-physical performance battery(Change from baseline to 12 and 24 weeks)