Comparing Mnemonic Strategy With Spaced Retrieval Training in Patients With Mild Cognitive Impairment (B6366-W)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment
研究概览
简要总结
This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.
详细描述
Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the "trained" stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Participants were informed they would receive one of two cognition oriented treatments but were unaware of the nature of the other intervention.
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of MCI according to Petersen (2004) criteria, right handed
排除标准
- •Diagnosis of other neurological condition,
- •active drug/alcohol abuse/dependence,
- •moderate-severe depression or other Axis I diagnoses.
研究组 & 干预措施
Mnemonic strategy training
Training using mnemonic strategies
干预措施: mnemonic strategy training (Behavioral)
Spaced retrieval training
Training using spaced retrieval
干预措施: spaced retrieval training (Behavioral)
结局指标
主要结局
Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment
时间窗: up to 1 month after last training session
Change in memory for 45 trained object location associations
次要结局
- Change in Accuracy (vs. Baseline) on Novel Object Location Associations(up to 1 month after last training session)