A paediatric intensive care study comparing the use of non-absorbable antibiotics and standard infection control to prevent secondary infection in critically ill childre

Not Applicable

Completed

• Conditions: Digestive tract infection in critically ill children; Infections and Infestations

• Registration Number: ISRCTN40310490
• Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Brief Summary

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35277414/ (added 14/03/2022) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/38066012/ (added 11/12/2023) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38421007/ (added 01/03/2024)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-10-30
• Study Completion: 2022-10-31
• Last Update Posted: 11 March 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 361

Inclusion Criteria

Pilot cRCT:
1. Aged >37 weeks (corrected gestational age) and <16 years
2. Receiving mechanical ventilation expected to last at least 48 h (and expected to remain so until the day after tomorrow)

Mixed methods study:
3. Online survey/telephone interviews: All health care professionals working in a PICU within the UK
4. Focus Groups: All healthcare professionals working in the two PICUs selected for focus groups
5. Survey/telephone interviews: Parents/legal representatives of all recruited patients

Exclusion Criteria

1. Known allergy, sensitivity or interaction to polymyxin E, tobramycin, or nystatin
2. Known to be pregnant
3. Death perceived as imminent

Study & Design

• Study Type: Interventional
• Study Design: Not specified