Culture Media for Borrelia Burgdorferi Sensu Lato
Not Applicable
Completed
- Conditions
- Erythema Migrans
- Registration Number
- NCT02145754
- Lead Sponsor
- University Medical Centre Ljubljana
- Brief Summary
The main purpose of this study is to compare effectiveness of two different culture media for cultivation of Borrelia burgdorferi sensu lato from skin specimens obtained from patients with erythema migrans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 235
Inclusion Criteria
- erythema migrans in patients > 18 years
Exclusion Criteria
- pregnancy or lactation
- taking antibiotic with antiborrelial activity within 10 days
- erythema migrans localized on face or neck
Each patient (235 subjects) provided two skin samples (470 skin samples).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Detection of Borrelia Burgdorferi Sensu Lato by Microscopy in Dark Field (Positive vs. Negative) weekly examination during 9 weeks of cultivating for individual specimen number of erythema migrans skin samples with Borrelia Burgdorferi sensu lato detected by Microscopy in Dark Field
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms enhance Borrelia burgdorferi cultivation in modified culture media for erythema migrans diagnostics?
How do the culture media in NCT02145754 compare to standard-of-care methods for isolating Borrelia burgdorferi from skin biopsies?
Which biomarkers correlate with successful Borrelia burgdorferi culture in patients with early Lyme disease manifestations like erythema migrans?
What are the potential adverse events associated with prolonged Borrelia burgdorferi culture and how are they mitigated in clinical practice?
Are there alternative antimicrobial agents or combination therapies that improve Borrelia burgdorferi detection in culture media for Lyme disease research?
Trial Locations
- Locations (1)
UMC Ljubljana, Department of Infectious Diseases
🇸🇮Ljubljana, Slovenia
UMC Ljubljana, Department of Infectious Diseases🇸🇮Ljubljana, Slovenia