Comparison of post operative pain relief in cesarean delivery with buprenorphine and morphine when used along with 0.25%bupivacaine in ultrasound guided transversus abdominis plane block.

Phase 2/3

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/07/035203
• Lead Sponsor: M MUGUNDA RAJ

Brief Summary

Post operative pain in cesarean delivery is of utmost concern, inadequate pain relief may lead to Poor recovery and prolong hospital stay. Hence it require a multimodal approach, as transversus abdominis plane has extended course of subcostal, ilioinguinal, iliohypogatric and genitofemoral nerves.A transversus abdominis plane (TAP) block is more appropriate in lower abdominal surgeries.As blind injections can result in inadvertent injury to bowel or blood vessels using ultrasound guided transversus abdominis plane block is more is more appropriate. Bupivacaine has shown its efficacy in providing post operative analgesia for 6 to 8hours adding an adjuvant will prolong its effect.In this study we are about to compare the post operative analgesic effect of buprenorphine and morphine when added as adjuvant to 0.25% bupivacaine in ultrasound guided transversus abdominis plane block, in patient undergoing cesarean delivery.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-07-27
• Study Start: 2021-08-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

Patient with ASA physical status-2 posted for cesarean delivery.

Exclusion Criteria

• Chronic pain disorder 2.
• Known allergy or hypersensitivity to the study drug 3.
• Coagulopathy 4.local infection at block site 5.patient refusal for the procedure.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart rate,	All these parameters are measured every 15mins for 1st hour,then every hourly upto 12hours,Then every 4th hourly upto 24hours.
Post operative pain assessment (VAS score),	All these parameters are measured every 15mins for 1st hour,then every hourly upto 12hours,Then every 4th hourly upto 24hours.
Respiratory rate,	All these parameters are measured every 15mins for 1st hour,then every hourly upto 12hours,Then every 4th hourly upto 24hours.
Blood pressure,	All these parameters are measured every 15mins for 1st hour,then every hourly upto 12hours,Then every 4th hourly upto 24hours.
Oxygen saturation.	All these parameters are measured every 15mins for 1st hour,then every hourly upto 12hours,Then every 4th hourly upto 24hours.

Secondary Outcome Measures

Name	Time	Method
24 hour analgesic consumption, nausea, vomiting, pruritis,	Monitored for 24 hours

Trial Locations

Locations (1)

Sri manakula vinayagar medical college and hospital; 🇮🇳 Pondicherry, PONDICHERRY, India

Sri manakula vinayagar medical college and hospital

🇮🇳Pondicherry, PONDICHERRY, India

M MUGUNDA RAJ

Principal investigator

9894228804

mugunthraj94@gmail.com